{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:31:08Z","timestamp":1790652668976,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent respiratory papillomatosis (RRP) is a respiratory tract disease that affects children and adults and is characterized by the recurrent proliferation of multiple papillomas. The etiologic agent is the human papillomavirus, mainly genotypes 6 and 11. Furthermore, polymorphisms in <jats:italic>TAP1<\/jats:italic> appear to influence the selection of antigenic peptides and the transport process to the rough endoplasmic reticulum, for their subsequent presentation to T lymphocytes, an essential process against viral diseases and tumor processes. Previous studies have shown that individuals with those polymorphisms are susceptible to immune, infectious, and tumor\u2010related diseases. The present study aimed to determine the association between the <jats:italic>TAP1<\/jats:italic> rs1057141 (c.1177A&gt;G) and rs1135216 (c.2090A&gt;G) single nucleotide polymorphisms (SNPs) and RRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was carried out on a group of 70 individuals (35 controls and 35 patients). RRP diagnosis, HPV genotyping, and viral load were determined through histology and PCR. SNPs rs1057141 and rs1135216 were identified through allelic discrimination, using real\u2010time PCR. The haplotypic analyses were performed using the Arlequin 3.5 program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HPV\u20106 and HPV\u201011 were the genotypes found in the samples. In the polymorphism analysis, rs1057141 showed no significant differences (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.049, CI\u00a0=\u00a00.994\u20137.331). In contrast, a significant difference was found in rs1135216 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.039, OR\u00a0=\u00a02.4) in the allelic analysis, as well as in the dominant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027, OR\u00a0=\u00a03.06), codominant (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.033, OR\u00a0=\u00a03.06), and additive model (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.043, OR\u00a0=\u00a02.505) in subjects with the G allele.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The G allele in rs1135216 was associated with a genetic risk of susceptibility for RRP in a population in Western Mexico.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23712","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T22:36:04Z","timestamp":1611873364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between the <i>TAP1<\/i> gene polymorphisms and recurrent respiratory papillomatosis in patients from Western Mexico: A pilot study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-2327","authenticated-orcid":false,"given":"Jaime","family":"Palomares\u2010Marin","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Humberto","family":"Govea\u2010Camacho","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda Cabeza y uello Centro M\u00e9dico Nacional de Occidente IMSS Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Araujo\u2010Caballero","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda Cabeza y uello Centro M\u00e9dico Nacional de Occidente IMSS Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Cazarez\u2010Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Yair","family":"Rodriguez\u2010Preciado","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ortiz\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Servicio de Otorrinolaringolog\u00eda Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Martinez\u2010Lopez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular y Gen\u00f3mica Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-9260","authenticated-orcid":false,"given":"Jose Francisco","family":"Mu\u00f1oz\u2010Valle","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Ciencias Biom\u00e9dicas Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2203-0978","authenticated-orcid":false,"given":"Ivan Isidro","family":"Hernandez\u2010Ca\u00f1averal","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Patolog\u00eda Centro Universitario de Ciencias de la Salud Universidad de Guadalajara Guadalajara M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-11-114"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216697"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"e203\u20106","article-title":"Recurrent respiratory papillomatosis. Case report","volume":"113","author":"Cong LT","year":"2015","journal-title":"Arch Argent Pediatr"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2017.03.030"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"90","article-title":"The role of Human papilloma virus (HPV) genotyping in recurrent respiratory papillomatosis in Rasoul Akram Hospital","volume":"26","author":"Izadi F","year":"2012","journal-title":"Med J Islam Repub Iran"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.1.79-85.2000"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/381764"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2012.03.006"},{"issue":"8","key":"e_1_2_8_12_1","first-page":"10","article-title":"Structure and dynamics of antigenic peptides in complex with TAP","volume":"30","author":"Lehnert E","year":"2017","journal-title":"Front Immunol"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"62","article-title":"Association of TAP1 and TAP2 gene polymorphisms with susceptibility to pulmonary tuberculosis","volume":"15","author":"Naderi M","year":"2016","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.725090"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2010.02.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1883"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0185-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.6.1304-1310.1997"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02749-13"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1994.tb02388.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.07.304"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.4.363"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.22953"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23808"},{"issue":"7","key":"e_1_2_8_25_1","first-page":"1973","article-title":"Human papillomavirus (HPV) genotype distribution in patients with recurrent respiratory papillomatosis (RRP) in Iran","volume":"18","author":"Eftekhaar NS","year":"2017","journal-title":"Asian Pacific J Cancer Prevent"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.7.711"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2103-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363835"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033051"},{"key":"e_1_2_8_30_1","first-page":"238","article-title":"Transporter associated with antigen processing 1637A\/G gene polymorphisms and susceptibility to nasopharyngeal carcinoma in Han population in Yunnan Province, China","volume":"45","author":"Sui J","year":"2010","journal-title":"Zhonghua er bi yan hou tou jing wai ke za zhi = Chin J Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23458"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.06.012"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23712","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:40:39Z","timestamp":1693618839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jcla.23712"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23712","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23712"}}