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Due to the lack of a comprehensive study, this study aimed to investigate the <jats:italic>CD209<\/jats:italic> promoter variants and haplotypes in a Taiwanese population and the association with RA development. Deoxyribonucleic acid (DNA) of peripheral blood mononuclear cells from 126 RA patients and 124 healthy controls was purified, and the <jats:italic>CD209<\/jats:italic> gene promoter was amplified by polymerase chain reaction and analyzed by Sanger sequencing. Results showed that a novel variant \u221296C&gt;A polymorphism in <jats:italic>CD209<\/jats:italic> promoter was identified in the Taiwanese population, and the frequency was significantly higher in RA patients than in controls (11.51% vs. 2.42%, P\u00a0&lt;\u00a0.0001). The odds ratio (OR) for the development of RA was 5.88 (95% CI 2.35\u201314.74, P\u00a0&lt;\u00a0.0001). Other known variants were also evaluated; for instance, \u22121180\u00a0T\/T (rs7359874) was increased in RA patients, and the OR for the development of RA was 3.26, 95% CI 0.85\u201312.52, P\u00a0=\u00a0.07). Besides, the haplotype frequencies were calculated; \u22121180A\u2010939C\u2010871\u00a0T\u2010336\u00a0T\u2010139\u00a0T\u201096A and \u22121180\u00a0T\u2010939\u00a0T\u2010871C\u2010336\u00a0T\u2010139C\u201096A were increased in RA patients (P\u00a0=\u00a0.004 and 0.05, respectively). In summary, CD209\u201096A variant could be an important factor for the development of RA in the Taiwanese population.<\/jats:p>","DOI":"10.1002\/jcla.23751","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T12:26:54Z","timestamp":1617280014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel <i>CD209<\/i> polymorphism is associated with rheumatoid arthritis patients in Taiwan"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7016-8392","authenticated-orcid":false,"given":"Hua\u2010Chen","family":"Chan","sequence":"first","affiliation":[{"name":"Center for Lipid Biosciences Kaohsiung Medical University Hospital Kaohsiung City 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