{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:19Z","timestamp":1785148339449,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To discuss the clinical significance of HCV\u2010cAg testing in the diagnosis, activity determination, and monitoring of therapeutic effectiveness of HCV infection and its advantages compared with HCV\u2010RNA and anti\u2010HCV antibodies detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By summarizing the published literature, the advantages and significance of HCV core antigen detection were sought.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The expression of HCV\u2010cAg is highly consistent with that of HCV\u2010RNA, but compared with HCV\u2010RNA, detection of HCV\u2010cAg is easy to operate, time saving, and low cost. HCV\u2010cAg can be detected within 12~15\u00a0days after infection, and the window period can be shortened by5~7\u00a0weeks. HCV\u2010cAg is a serological indicator of virus replication, which can distinguish previous infection of HCV or current infection. HCV\u2010cAg detection is more suitable for immunocompromised, hemodialysis, organ transplant patients. HCV\u2010cAg also can be used to monitor antiviral efficacy and predict sustained virological response (SVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HCV core antigen has similar clinical sensitivity to NAT and can be used as a substitute for HCV\u2010RNA in the diagnosis of virus infection. Combined detection of HCV\u2010cAg and antibody serology can help doctors detect HCV infection earlier, accurately diagnose different stages of HCV infection, and evaluate the therapeutic effect of antiviral drugs, which are beneficial in the prevention and treatment of hepatitis C.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23755","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T11:46:58Z","timestamp":1617191218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["HCV core antigen plays an important role in the fight against HCV as an alternative to HCV\u2010RNA detection"],"prefix":"10.1002","volume":"35","author":[{"given":"Yuhan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Transfusion The Affiliated Hospital of Southwest Medical University Luzhou 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