{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:41Z","timestamp":1753869401798,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Different disease severities of COVID\u201019 patients could be reflected on clinical laboratory findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010centered retrospective study, demographic, clinical, and laboratory indicators on and during admission were compared among 74 participants with mild, moderate, critical severe, or severe classification. Risk factors associated with disease severity were analyzed by multivariate analyses. The AUC and 95% CI of the ROC curve were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common manifestations of these patients were fever and cough. Critical severe or severe group owned the longest length of stay (23 (19,31), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). After multivariate logistic regression, independent influence factors on admission for severity of disease were CK\u2010MB (OR 0.674; 95% CI 0.489\u20130.928; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016), LDH (OR 1.111 or 1.107; 95% CI 1.026\u20131.204 or 1.022\u20131.199; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009 or 0.013), normal T\u2010BIL (OR 4.58\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>; 95% CI 3.05\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>\u20136.88\u00a0\u00d7\u00a010<jats:sup>\u22127<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), LYM% (OR 0.008; 95% CI 0\u20130.602; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), and normal ESR (OR 0.016; 95% CI 0\u20130.498; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019). Factors during hospitalization were normal T\u2010BIL (OR 8.56\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>; 95% CI 8.30\u00a0\u00d7\u00a010<jats:sup>\u221210<\/jats:sup>\u20138.83\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), LYM (OR 0.068; 95% CI 0.005\u20130.934; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.044), albumin (OR 0.565; 95% CI 0.327\u20130.977; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041), and normal NEU% (OR 0.013; 95% CI 0.000\u20130.967; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048). Combined indicators of AUC were 0.860 (LYM, LDH, and normal ESR on admission, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and 0.750 (CK\u2010MB, LDH, and normal T\u2010BIL during hospitalization, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020) when predicting for severe or critical severe patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To pay close attention to the progression of COVID\u201019 and take measures promptly, we should be cautious of the laboratory indicators when patients on admission especially CK\u2010MB, LDH, LYM%, T\u2010BIL as well as ESR; and T\u2010BIL, LYM, albumin, NEU% with the process of disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23767","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T06:09:36Z","timestamp":1620281376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cautions on the laboratory 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