{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:12:37Z","timestamp":1784265157512,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Altered level of many hematological parameters such as white blood cells (WBC) and platelet function has been observed in diabetes mellitus (DM) patients. Therefore, this study aimed to determine the WBC and platelet profiles and their association with anthropometric measurement and blood pressure in DM patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A comparative cross\u2010sectional study was conducted on a total of 246 participants at the University of Gondar Specialized Referral Hospital. Venous blood with K<jats:sub>2<\/jats:sub> EDTA anticoagulant was drawn and analyzed by using Sysmex KX21N hematology analyzers for WBC and platelet parameters. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results were presented as frequency and mean\u00a0\u00b1\u00a0standard deviation (SD). The independent sample <jats:italic>t<\/jats:italic> test was used to compare quantitative variables between DM and control groups. The bivariate (spearman's rank) correlation was used to analyze continuous variables. A <jats:italic>p<\/jats:italic>\u2010value\u00a0\u02c2\u00a00.05 was considered as statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean platelet count was significantly higher among diabetics (252.77\u00a0\u00b1\u00a077.7) compared to non\u2010diabetic controls (208.22\u00a0\u00b1\u00a068), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001. Similarly, the total WBC count was higher among DM patients (6.95\u00a0\u00b1\u00a02.23) than in the controls (6.15\u00a0\u00b1\u00a01.95), <jats:italic>p\u00a0<\/jats:italic>=\u00a00.04. A significant negative correlation was also found between neutrophil and duration of illness in DM patients. Besides, there is a significant positive correlation between WBC and lymphocyte number with systolic blood pressure (SBP) in DM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet and WBC count were significantly higher in DM patients than in the controls. Therefore, routine screening and profile checking of those abnormal indices is recommended to minimize DM\u2010related complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23808","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T11:12:07Z","timestamp":1620040327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross\u2010sectional study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-5755","authenticated-orcid":false,"given":"Tiruneh","family":"Adane","sequence":"first","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikir","family":"Asrie","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zegeye","family":"Getaneh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Getawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-S062"},{"key":"e_1_2_9_3_1","volume-title":"Global Status Report on Noncommunicable Diseases 2010","author":"Alwan A","year":"2011"},{"key":"e_1_2_9_4_1","first-page":"28","article-title":"Study of hematological indices in patients with diabetes mellitus and hypertensive diabetes mellitus","volume":"1","author":"Shukla D","year":"2016","journal-title":"Indian J Med Res"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.7.1710"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2017.12.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00836.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/742719"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164110383994"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2331-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0953710042000267707"},{"key":"e_1_2_9_13_1","first-page":"425","article-title":"Mean platelet volume increases in type 2 diabetes mellitus independent of HbA1c level","volume":"30","author":"Cakir L","year":"2014","journal-title":"Acta Med Mediterr"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.10.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.15562\/bmj.v7i3.806"},{"key":"e_1_2_9_16_1","first-page":"417","article-title":"Mean platelet volume: an overlooked herald OF malignant thyroid nodules","volume":"58","author":"Sit M","year":"2019","journal-title":"Acta Clin Croat"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.18071\/isz.69.0411"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066617703348"},{"key":"e_1_2_9_19_1","first-page":"160","article-title":"Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome","volume":"9","author":"Aktas G","year":"2014","journal-title":"Prz Gastroenterol"},{"key":"e_1_2_9_20_1","first-page":"71","article-title":"Does mean platelet volume decrease in the presence of coronary artery fistula?","volume":"113","author":"Sincer I","year":"2019","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2013.011"},{"key":"e_1_2_9_22_1","first-page":"1263","article-title":"Mean platelet volume should be a useful indicator in diagnosis of Hashimoto's thyroiditis","volume":"30","author":"Sit M","year":"2014","journal-title":"Acta Med Mediterr"},{"key":"e_1_2_9_23_1","first-page":"44","article-title":"Thrombocytopenia in adults","volume":"1","author":"Erkurt MA","year":"2012","journal-title":"J Hematol"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S137067"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_9_26_1","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"Levey AS","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"e_1_2_9_27_1","first-page":"2165","article-title":"Some haematological parameters in patients with type\u20101 diabetes in Sokoto North Western Nigeria","volume":"3","author":"Uko E","year":"2013","journal-title":"J Blood Lymph"},{"key":"e_1_2_9_28_1","first-page":"e5296","article-title":"Abnormal hematological indices and anthropometric parameters associated with type 2 Diabetes","volume":"10","author":"Olana C","year":"2019","journal-title":"Int J Adv Res"},{"key":"e_1_2_9_29_1","first-page":"11420","article-title":"Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes","volume":"8","author":"Demirtas L","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.65.1.38"},{"key":"e_1_2_9_31_1","first-page":"96","article-title":"Are platelet indices useful in the evaluation of type 2 diabetic patients?","volume":"52","author":"Alhadas KR","year":"2016","journal-title":"J Bras Patol Med Lab"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000091257.27563.32"},{"key":"e_1_2_9_33_1","first-page":"6280","article-title":"Significance of hematological parameters in uncomplicated diabetes mellitus","volume":"14","author":"Bhatt N","year":"2020","journal-title":"Indian J Forensic Med Toxicol"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2004.01320.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00485-2"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.5.489"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(02)00348-1"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00099-4"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1632283"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.66.2.160"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2019.1643310"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-489X.210115"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S97563"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20174111"},{"key":"e_1_2_9_46_1","volume-title":"Haematological Profile of Diabetes and Non\u2010Diabetes Patients in Abuja","author":"Umeji L","year":"2019"},{"key":"e_1_2_9_47_1","first-page":"1","article-title":"A comparative analysis of biochemical and hematological parameters in diabetic and non\u2010diabetic adults","volume":"2","author":"Alam J","year":"2015","journal-title":"An Inter J"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i1.35"},{"key":"e_1_2_9_49_1","first-page":"14","article-title":"Study of hematological profile and its significance in type 2 diabetes mellitus patients","volume":"1","author":"Bharathi K","year":"2016","journal-title":"J Diagn Pathol Oncol"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5214376"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110505497"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03229.x"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S275392"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.131"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-6-50"},{"key":"e_1_2_9_56_1","first-page":"163","article-title":"Relationship between lipid and hematological profiles with adiposity in obese adolescents","volume":"35","author":"Ferreira LCCdN","year":"2013","journal-title":"Rev Bras Hematol Hemoter"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23808","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23808","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T19:30:05Z","timestamp":1693423805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/jcla.23808"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23808","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2021-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23808"}}