{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:16:36Z","timestamp":1777482996740,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serum uric acid (SUA) is a key risk factor contributing to renal failure, a serious public health problem. However, few studies have examined whether the interactive relationship between alcohol consumption and SUA is independently associated with the estimated glomerular filtration rate (eGFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our sample comprised 742 men aged 69\u00a0\u00b1\u00a011\u00a0years (mean\u00a0\u00b1\u00a0standard deviation) and 977 women aged 69\u00a0\u00b1\u00a010\u00a0years from a rural area. We cross\u2010sectionally examined the relationships between the confounding factors of alcohol consumption and SUA with renal function denoted by eGFR estimated using CKD\u2010EPI (Chronic Kidney Disease Epidemiology Collaboration) equations modified by a Japanese coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both genders, eGFR increased with a rise in alcohol consumption. This tendency was more pronounced in participants with hyperuricemia, where SUA was greater than 7.0\u00a0mg\/dL in men and greater than 6.0\u00a0mg\/dl in women (men: <jats:italic>F<\/jats:italic>\u00a0=\u00a041.98, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; women: <jats:italic>F<\/jats:italic>\u00a0=\u00a041.98, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). A multiple linear regression analysis showed that alcohol consumption (men: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.112, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; women: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.060, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) and SUA (men: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a0\u22120.282, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; women: <jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.317, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were significantly and independently related to eGFR. Further, the interactive relationship between alcohol consumption and SUA (men: <jats:italic>F<\/jats:italic>\u00a0=\u00a06.388, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; women: <jats:italic>F<\/jats:italic>\u00a0=\u00a05.368, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) was a significant and independent indicator of eGFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggested that alcohol consumption and SUA were synergistically associated with renal dysfunction among community\u2010dwelling persons.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23812","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T20:50:42Z","timestamp":1620507042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alcohol consumption and serum uric acid are synergistically associated with renal dysfunction among community\u2010dwelling 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Hospital Seiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Ehime University Graduate School of Medicine Toon Japan"},{"name":"Department of Internal Medicine Seiyo Municipal Nomura Hospital Seiyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Tokumoto","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teru","family":"Kumagi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Ehime University Graduate School of Medicine Toon 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