{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:12Z","timestamp":1790172432218,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370165 to SB"],"award-info":[{"award-number":["81370165 to SB"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic nephropathy is a kidney disease caused by long\u2010term hyperglycemia. Hsa_circRNA_102682 is related to the pathogenesis of preeclampsia. Preeclampsia is related to hypertension and proteinuria, and diabetic nephropathy is mainly manifested by hypertension and proteinuria. The main pathological change in diabetic nephropathy is glomerular fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used serum samples of patients treated at Li Huili Eastern Hospital, Ningbo, China, from July 10, 2018 to February 15, 2019. We included 73 patients with diabetes and divided them into a normal\u2010homocysteine group and a high\u2010homocysteine group. We selected used quantitative reverse transcriptase\u2010polymerase chain reaction to measure Hsa_circRNA_102682 concentration in the serum. Serum transforming growth factor\u2010beta and connective tissue growth factor levels were tested using ELISA. The Pearson correlation test was used to assess the correlations between Hsa_circRNA_102682, transforming growth factor\u2010beta, connective tissue growth factor, homocysteine, and creatinine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Hsa_circRNA_102682 was significantly lower in diabetic patients with high levels of homocysteine than in those with normal levels of homocysteine, whereas transforming growth factor\u2010beta and connective tissue growth factor levels were higher in diabetic patients with hyperhomocysteinemia. Hsa_circRNA_102682 was negatively correlated with the levels of transforming growth factor\u2010beta, connective tissue growth factor, homocysteine, and creatinine. Transforming growth factor\u2010beta and connective tissue growth factor were both positively correlated with homocysteine and creatinine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low Hsa_circRNA_102682 was associated with high levels of transforming growth factor\u2010beta and connective tissue growth factor as well as homocysteine and creatinine. These results suggest that Hsa_circRNA_102682\u00a0might be related to the pathogenesis of hyperhomocysteinemia in diabetic nephropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23860","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T07:18:27Z","timestamp":1627024707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lower expression of Hsa_circRNA_102682 in diabetic hyperhomocysteinemia negatively related to creatinemia is associated with TGF\u2010\u03b2 and CTGF"],"prefix":"10.1002","volume":"35","author":[{"given":"Fei","family":"Hu","sequence":"first","affiliation":[{"name":"Diabetes Research Center School of Medicine Ningbo University Ningbo China"},{"name":"Zhejiang Provincial Key Laboratory of Pathophysiology Department of Biochemistry and Molecular Biology School of Medicine Ningbo University Ningbo China"},{"name":"Cixi Biomedical Research Institute Wenzhou Medical University Cixi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Sha","sequence":"additional","affiliation":[{"name":"Diabetes Research Center School of Medicine Ningbo University Ningbo China"},{"name":"Zhejiang Provincial Key Laboratory of Pathophysiology Department of Biochemistry and Molecular Biology School of Medicine Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixue","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of endocrinology Ninghai Chengguan Hospital Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of endocrinology Ninghai Chengguan Hospital Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of endocrinology 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