{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:34Z","timestamp":1790806414779,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We established age\u2010group\u2010specific reference intervals for serum anti\u2010M\u00fcllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed serum levels of AMH, follicle\u2010stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS. Age\u2010group\u2010specific reference intervals and AMH diagnostic performance were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PCOS group had a median AMH level of 7.0\u00a0\u00b5g\/L, which was higher than for the healthy (1.8\u00a0\u00b5g\/L) and the benign gynecologic diseases (2.7\u00a0\u00b5g\/L) groups. The upper 97.5% reference limits for age groups 12\u201320\u00a0years, 21\u201334\u00a0years, and 35\u201346\u00a0years were 13.2\u00a0\u00b5g\/L, 15.8\u00a0\u00b5g\/L, and 6.6\u00a0\u00b5g\/L, respectively. The area under the curve (AUC) values to estimate AMH ability to discriminate PCOS from healthy women for each age group were 0.741, 0.785, and 0.789, respectively. AUCs for LH\/FSH were 0.719, 0.672, and 0.590.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The better diagnostic ability of AMH over LH\/FSH in women of late childbearing ages indicates that age and other clinical characteristics should be considered when interpreting these test results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23861","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T20:10:43Z","timestamp":1623183043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Age\u2010group\u2010specific reference intervals for anti\u2010M\u00fcllerian hormone and its diagnostic performance for polycystic ovary syndrome in a Korean population"],"prefix":"10.1002","volume":"35","author":[{"given":"Junhyup","family":"Song","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5668-4120","authenticated-orcid":false,"given":"Yongjung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Weon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-3660","authenticated-orcid":false,"given":"Sang\u2010Guk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Baeck","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine Seoul Republic of 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