{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:38:16Z","timestamp":1770824296452,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Test utilization for the diagnosis of celiac disease may affect the prevalence and incidence of the disease in Korea. We aimed to investigate the test utilization of serological biomarkers for celiac disease in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively investigated the test utilization of tissue transglutaminase IgA, gliadin IgA and IgG, and endomysial IgA antibody (Ab) assays between January 2011 and June 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a nine\u2010year\u2010and\u2010six\u2010month study period, overall 307,322,606 clinical tests were requested from different clinical settings, such as local clinics, hospitals, university hospitals, and tertiary medical centers. Among them, only 58 tissue transglutaminase IgA, 22 gliadin IgA, 12\u00a0gliadin IgG, and 16 endomysial IgA Ab tests were performed on 79\u00a0Korean patients. Among them, one patient had positive transglutaminase IgA Ab result (1.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low prevalence and incidence of celiac disease in Korea may be due to an underutilization of diagnostic assays.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23913","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T12:23:15Z","timestamp":1635078195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Underutilization of diagnostic assays for celiac disease in Korea"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-2248","authenticated-orcid":false,"given":"Rihwa","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Genetics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Department of Laboratory Medicine Green Cross Laboratories Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4672-5811","authenticated-orcid":false,"given":"Sang Gon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Green Cross Laboratories Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-175X","authenticated-orcid":false,"given":"Eun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Green Cross Laboratories Yongin Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0421"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13270"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15737"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12352"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2018.09.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2013.61.6.338"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2015.30.1.105"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2017.15.4.540"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640619844125"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.282"},{"key":"e_1_2_8_14_1","unstructured":"National Health Insurance Service.Operational structure of Korea health care system \u2010 the governance of Korean health care system. Accessed September 23 2021.https:\/\/www.nhis.or.kr\/static\/html\/wbd\/g\/a\/wbdga0401.html"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23913","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23913","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23913","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:06:30Z","timestamp":1693191990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/jcla.23913"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23913","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]},"assertion":[{"value":"2021-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23913"}}