{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:33:35Z","timestamp":1774467215464,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alzheimer's disease (AD) has a prolonged preclinical stage characterized by cognitive dysfunction. Simple, reliable, and noninvasive biomarkers reflecting the pathogenesis of AD are needed for screening cognitive dysfunction in primary health care. The aims of this study were to determine (1) the potential utility of the Multimer Detection System\u2010Oligomeric Amyloid\u2010\u03b2 (MDS\u2010OA\u03b2) value in cognitive assessments and (2) the reference interval (RI) of plasma MDS\u2010OA\u03b2 values in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study consecutively recruited 1,594 participants who underwent health checkups including cognitive function examination at 16\u00a0health\u2010promotion centers in Korea between December 2020 and January 2021. The inBlood<jats:sup>TM<\/jats:sup> OA\u03b2 test (PeopleBio, Gyeonggi\u2010do, Republic of Korea) was utilized to quantify MDS\u2010OA\u03b2 values in plasma. The reference subjects were obtained among those with normal general cognition on cognitive screening tools. RIs were established according to the CLSI C28\u2010A3\u00a0guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median MDS\u2010OA\u03b2 value was higher in subjects with Korean Dementia Screening Questionnaire\u2010Cognition (KDSQ\u2010C) scores \u22658 than in those with KDSQ\u2010C scores of 6\u20137 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.013). The median MDS\u2010OA\u03b2 value was higher in subjects with Mini\u2010Mental State Examination for Dementia Screening (MMSE\u2010DS) scores of 21\u201326 than in those with MMSE\u2010DS scores \u226527 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.011). The RI (one\u2010side upper 95th percentile) of the MDS\u2010OA\u03b2 value was 0.80\u00a0ng\/mL (95% confidence interval\u00a0=\u00a00.78\u20130.82) in those aged \u226550\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The plasma MDS\u2010OA\u03b2 value reflects cognitive function as assessed using the KDSQ\u2010C and MMSE\u2010DS. RIs obtained from a large and cognitively healthy community\u2010based sample are presented.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23933","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T08:31:47Z","timestamp":1627979507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reference interval and the role of plasma oligomeric beta amyloid in screening of risk groups for cognitive dysfunction at health checkups"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0637-4364","authenticated-orcid":false,"given":"Eun\u2010Hee","family":"Nah","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeran","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwon","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inhwan","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Health Promotion Research Institute Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Ik","family":"Cho","sequence":"additional","affiliation":[{"name":"MEDIcheck LAB Korea Association of Health Promotion  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.7.903"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001774"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S152163"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011666140317103222"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3178"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179941"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811698106"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-017-0310-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200061"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"135","article-title":"The development and validation of Korean Dementia Screening Questionnaire (KDSQ)","volume":"20","author":"Yang DW","year":"2002","journal-title":"J Korean Neurol Assoc"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"27","article-title":"A normative study of the Mini\u2010Mental State Examination for Dementia Screening (MMSE\u2010DS) and its short form (SMMSE\u2010DS) in the Korean Elderly","volume":"14","author":"Han JW","year":"2010","journal-title":"J Korean Geriatr Psychiatry"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"119","article-title":"Reliability and validity of the Korean version of the Patient Health Questionnaire\u20109 (PHQ\u20109)","volume":"6","author":"Park SJ","year":"2010","journal-title":"Anxiety Mood"},{"key":"e_1_2_9_18_1","volume-title":"Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; 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