{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:15:01Z","timestamp":1780611301107,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study was designed to evaluate the impact of polymorphisms in the urate transporter 1 (<jats:italic>URAT1<\/jats:italic>) gene on the uricosuric action of losartan therapy in hypertensive patients suffering from hyperuricemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A MassARRAY approach was used to detect single nucleotide polymorphism (SNP) loci in the <jats:italic>URAT1<\/jats:italic> and <jats:italic>CYP2C9<\/jats:italic>\u00a0genes (16 and 2\u00a0loci, respectively) in 111 patients with hypertension and hyperuricemia taking losartan and in 121\u00a0healthy controls. In addition, we compared serum urate (SUA) levels and other key clinical biochemistry indices between these two patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected significant differences between the two patient groups with respect to age, SUA, urea, creatine, triglycerides, high\u2010density lipoprotein, low\u2010density lipoprotein, and fasting plasma glucose (<jats:italic>all p<\/jats:italic>\u00a0&lt;\u00a00.05). In addition, we found that hypertensive patients with hyperuricemia were more likely to exhibit the\u00a0rs3825016(C\/T) (36.9% vs 21.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), and we determined that a 2\u2010week treatment course with losartan was associated with significant decreases in SUA values (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the <jats:italic>URAT1<\/jats:italic> rs3825016 polymorphism may influence the uricosuric action of losartan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23949","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:45:02Z","timestamp":1631148302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The impact of an <i>URAT1<\/i> polymorphism on the losartan treatment of hypertension and hyperuricemia"],"prefix":"10.1002","volume":"35","author":[{"given":"Liting","family":"Wu","sequence":"first","affiliation":[{"name":"Medical Laboratory Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Fan","sequence":"additional","affiliation":[{"name":"Medical Laboratory Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhumeng","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Laboratory Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delong","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2877-9349","authenticated-orcid":false,"given":"Wenfang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Shidong Hospital, Shidong Hospital Affiliated to University of Shanghai for Science and Technology Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp369"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315596119"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.053"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"499","article-title":"Human renal urate transpoter URAT1 mediates the transport of salicylate","volume":"52","author":"Ohtsu N","year":"2010","journal-title":"Nihon Jinzo Gakkai Shi"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00160"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.245"},{"key":"e_1_2_7_8_1","first-page":"2","article-title":"High frequency of SLC22A12 variants causing renal hypouricemia 1 in the Czech and Slovak Roma population; simple and rapid detection method by allele\u2010specific polymerase chain reaction","volume":"2","author":"Gabrikova D","year":"2015","journal-title":"Urolithiasis"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2002.121216"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20148"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009360"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.52"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-015-0208-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337370"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.08.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.112755"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34995"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2013.810228"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.100"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256440"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6442-0_5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7584"},{"issue":"4","key":"e_1_2_7_23_1","article-title":"URAT1 allele 6092(T\/C) polymorphism influence uricosuric action of losartan in hyperuricemia patients with hypertension","volume":"20","author":"Huang XH","year":"2015","journal-title":"Chin J Clin Pharmacol Ther"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00266358"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/7.12.1035"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1186-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15257770.2016.1168839"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00839.x"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23949","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23949","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:38:38Z","timestamp":1693208318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/jcla.23949"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23949","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]},"assertion":[{"value":"2020-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23949"}}