{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:20:07Z","timestamp":1790666407888,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011917","name":"Hormozgan University of Medical Sciences","doi-asserted-by":"publisher","award":["4000271"],"award-info":[{"award-number":["4000271"]}],"id":[{"id":"10.13039\/501100011917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Retinoblastoma is the most common primary intraocular malignancy in children less than 4\u00a0years. Retinoblastoma (RB) contains about 3%\u20135% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Conducted search results lead to 4070\u00a0studies. The title and abstract screening lead to 11\u00a0studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin\u2010fixed, paraffin\u2010embedded tissue blocks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The association between HPV and retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23981","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T06:15:22Z","timestamp":1630390522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["HPV infections in retinoblastoma: a systematic review"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3369-0856","authenticated-orcid":false,"given":"Saber","family":"Soltani","sequence":"first","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"},{"name":"Research Center for Clinical Virology Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Tabibzadeh","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Zandi","sequence":"additional","affiliation":[{"name":"Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran"},{"name":"Research Center for Clinical Virology Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Zakeri","sequence":"additional","affiliation":[{"name":"Department of Hematology Faculty of Medical Sciences Tarbiat Modares University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Akhavan Rezayat","sequence":"additional","affiliation":[{"name":"Department of Management &amp; Health Economics School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akam","family":"Ramezani","sequence":"additional","affiliation":[{"name":"Research Center for Clinical Virology Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Esghaei","sequence":"additional","affiliation":[{"name":"Department of Virology Faculty of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-2612","authenticated-orcid":false,"given":"Abbas","family":"Farahani","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.150292"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"283","article-title":"The diagnosis of retinoblastoma","volume":"64","author":"Abramson DH","year":"1988","journal-title":"Bull N Y Acad Med"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"103","article-title":"Epidemiology and Rb1 gene of retinoblastoma","volume":"4","author":"Yun J","year":"2011","journal-title":"Int J Ophthalmol"},{"issue":"101","key":"e_1_2_10_5_1","first-page":"7","article-title":"Understanding retinoblastoma: epidemiology and genetics","volume":"31","author":"Fabian ID","year":"2018","journal-title":"Comm Eye Health"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.820"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_21_19"},{"issue":"10","key":"e_1_2_10_8_1","first-page":"4010","article-title":"Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development","volume":"6","author":"Orjuela M","year":"2000","journal-title":"Clin Cancer Res"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2537532"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90983-5"},{"issue":"20","key":"e_1_2_10_11_1","first-page":"4620","article-title":"E7 protein of human papilloma virus\u201016 induces degradation of retinoblastoma protein through the ubiquitin\u2010proteasome pathway","volume":"56","author":"Boyer SN","year":"1996","journal-title":"Can Res"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000552"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e31818b373b"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7434012"},{"key":"e_1_2_10_15_1","first-page":"205","article-title":"Studies of JC virus\u2010induced nervous system tumors in the Syrian hamster: a review","volume":"105","author":"Zu GR","year":"1983","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300604"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_10_18_1","unstructured":"ViswanathanM BerkmanND DrydenDM HartlingL.Assessing Risk of Bias and Confounding in Observational Studies of Interventions or Exposures: Further Development of the RTI Item Bank. Rockville MD: Agency for Healthcare Research and Quality; Methods Research Report.2013. (Prepared by RTI\u2013UNC Evidence\u2010based Practice Center under Contract No. 290\u20102007\u201010056\u2010I) AHRQ Publication No. 13\u2010EHC106\u2010EF. www.effectivehealthcare.ahrq.gov\/reports\/final.cfm. [Accessed August 25 2021]."},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.139410"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.7.699"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/323643a0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006398232003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.11.1300"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13337-016-0319-7"},{"key":"e_1_2_10_26_1","first-page":"1","volume-title":"Human pathogenic papillomavirus types: an update, in Human pathogenic papillomaviruses","author":"De Villiers E\u2010M","year":"1994"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.690"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.16.2101"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21925"},{"issue":"2","key":"e_1_2_10_30_1","first-page":"229","article-title":"Human papillomavirus DNA in paraf\u03b2in\u2010embedded retinoblastoma","volume":"101","author":"Saktanasate J","year":"2018","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2013.27.5.368"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13337-019-00540-7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.199802"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23346"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011577"},{"issue":"20","key":"e_1_2_10_36_1","first-page":"5730","article-title":"Pre\u2010and postconception factors associated with sporadic heritable and nonheritable retinoblastoma","volume":"49","author":"Bunin GR","year":"1989","journal-title":"Can Res"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-018-00577-x"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23981","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:39:23Z","timestamp":1693208363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/jcla.23981"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23981","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"2021-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23981"}}