{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:10:06Z","timestamp":1760609406321,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Colchicine has the potential in reducing patient morbidity and mortality in COVID\u201019 infection owing to its anti\u2010inflammatory properties. This study aims to determine the efficacy of colchicine in optimizing inflammatory hematological biomarker levels among COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In accordance to Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) 2020 statement guidelines, a systematic search was conducted using the following keywords: Colchicine, covid*, SARS\u2010CoV\u20102, anti\u2010inflammatory, trials, clinical, hematological, laboratory. Databases were searched from December 2019 until August 26, 2021: MEDLINE\/PubMed, Web of Science, Cochrane, Scopus, and EMBASE. Other sources were located through ClinicalTrials.Gov, manually searching SAGE, Science Direct, Elsevier, and Google Scholar. The meta\u2010analysis was conducted using Review Manager 5.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, six studies were included, of which four reported c\u2010reactive protein (CRP) standardized mean reductions in the colchicine group (N\u00a0=\u00a0165) as opposed to the control (N\u00a0=\u00a0252; SMD\u00a0=\u00a0\u22120.49, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). On noting lactate dehydrogenase (LDH) values post treatment, the colchicine group (N\u00a0=\u00a0204) showed significant reductions at the end of treatment compared to control (N\u00a0=\u00a0290; SMD\u00a0=\u00a0\u22120.85, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Finally, the D\u2010dimer values in colchicine groups (N\u00a0=\u00a0129) compared to control (N\u00a0=\u00a0216) also documented a negative effect size (SMD\u00a0=\u00a0\u22120.9, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colchicine has efficacy in reducing inflammatory biomarkers observed in moderate\u2010to\u2010severe COVID\u201019 patients. It may be worthwhile to consider monitoring the clinical and laboratory parameters of patients in further trials to consider colchicine as a strong candidate for an adjunct to COVID\u201019 treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24057","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T10:56:21Z","timestamp":1635418581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Colchicine, COVID\u201019 and hematological parameters: A meta\u2010analysis"],"prefix":"10.1002","volume":"35","author":[{"given":"Musharraf","family":"Sarwar","sequence":"first","affiliation":[{"name":"University College of Medicine and Dentistry Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahid","family":"Ali","sequence":"additional","affiliation":[{"name":"Kyrgyz State Medical Academy Bishkek Bishkek Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnoor","family":"Fatima","sequence":"additional","affiliation":[{"name":"University College of Medicine and Dentistry Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-7455","authenticated-orcid":false,"given":"Zouina","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"Fatima Jinnah Medical University Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8206-5745","authenticated-orcid":false,"given":"Azza","family":"Sarfraz","sequence":"additional","affiliation":[{"name":"The Aga Khan University Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Cherrez\u2010Ojeda","sequence":"additional","affiliation":[{"name":"Universidad Espiritu Santo Samborondon Ecuador"},{"name":"Respiralab Research Group Guayaquil Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00019.2020"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-020-00230-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620937175"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-020-00432-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.017"},{"key":"e_1_2_10_8_1","first-page":"693","article-title":"Dexamethasone in hospitalized patients with Covid\u201019\u2014preliminary report","volume":"384","author":"Group TRC","year":"2020","journal-title":"N Engl J Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00222-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219174"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.13556"},{"key":"e_1_2_10_12_1","first-page":"n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"2021","author":"Page MJ","year":"2020","journal-title":"BMJ"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001455"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.13136"},{"key":"e_1_2_10_16_1","unstructured":"Colchicine plus phenolic monoterpenes to treat COVID\u201019 \u2010 study results \u2010 clinicaltrials.gov n.d.https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT04392141. 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