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Although molecular identification of the virus by polymerase chain reaction is the only recommended method in diagnosing COVID\u201019 infection, radiological, biochemical, and hematological studies are substantially important in risk stratification, patient follow\u2010up, and outcome prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This narrative review summarized the hematological changes including the blood indices, coagulative indicators, and other associated biochemical laboratory markers in different stages of COVID\u201019 infection, highlighting the diagnostic and prognostic significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search was conducted for multiple combinations of different hematological tests and manifestations with novel COVID\u201019 using the following key words: \u201chematological,\u201d \u201ccomplete blood count,\u201d \u201clymphopenia,\u201d \u201cblood indices,\u201d \u201cmarkers\u201d \"platelet\" OR \"thrombocytopenia\" AND \"COVID\u201019,\" \"coronavirus2019,\" \"2019\u2010nCoV,\" OR \"SARS\u2010CoV\u20102.\" Articles written in the English language and conducted on human samples between December 2019 and January 2021 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hematological changes are not reported in asymptomatic or presymptomatic COVID\u201019 patients. In nonsevere cases, hematological changes are subtle, included mainly lymphocytopenia (80.4%). In severe, critically ill patients and those with cytokine storm, neutrophilia, lymphocytopenia, elevated D\u2010dimer, prolonged PT, and reduced fibrinogen are predictors of disease progression and adverse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Monitoring hematological changes in patients with COVID\u201019 can predict patients needing additional care and stratify the risk for severe course of the disease. More studies are required in Iraq to reflect the hematological changes in COVID\u201019 as compared to global data.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24064","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T10:52:15Z","timestamp":1637059935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hematological changes associated with COVID\u201019 infection"],"prefix":"10.1002","volume":"36","author":[{"given":"Enass Abdul Kareem Dagher","family":"Al\u2010Saadi","sequence":"first","affiliation":[{"name":"Department of Pathology College of Medicine University of Kerbala Kerbala Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5405-9396","authenticated-orcid":false,"given":"Marwa Ali","family":"Abdulnabi","sequence":"additional","affiliation":[{"name":"Department of pathology Al\u2010Kindy College of Medicine University of Baghdad Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00607-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_9_4_1","unstructured":"European Centre for Disease Prevention and ControlCOVID\u201019 situation update worldwide: European Centre for Disease Prevention and Control; 2020.https:\/\/www.ecdc.europa.eu\/en\/about\u2010ecdc. 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