{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:17:51Z","timestamp":1782476271110,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702060"],"award-info":[{"award-number":["81702060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure and evaluate the distribution and possible contributing factors of seven bone metabolism\u2010associated biomarkers in Tibet, a plateau province of China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1615 individuals were recruited from Tibet at three different altitudes. The levels and possible contributing factors of serum calcium, serum phosphorus, ALP, 25OHD, PINP, CTX, and PTH were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1246 Tibetan adults (males: <jats:italic>n<\/jats:italic>\u00a0=\u00a0543) were eventually enrolled in this study. Multiple linear regression recognized age, sex, altitude, and BMI as the major effect factors. The levels of ALP, PINP, and CTX in males continuously decreased with age; however, those in females increased after approximately 39\u00a0years of age. Males had higher 25OHD levels (23.9 vs. 15.4\u00a0ng\/ml) but lower levels of serum phosphorus (1.12 vs. 1.19\u00a0mmol\/L) and PTH (41.3 vs. 47.4\u00a0pg\/ml) than females. Before the age of 50, males had higher levels of calcium, ALP, PINP, and CTX than females, and the opposite trend was observed after the age of 50. The highest levels of serum calcium and phosphorus and the lowest levels of PINP and CTX were found in the Shigatse\/Lhasa region, suggesting a better bone metabolism status. Compared with reports from plain areas of China, significantly higher levels of PINP (65.3 vs. 49.36\u00a0ng\/ml) and CTX (0.46 vs. 0.37\u00a0ng\/ml) were recorded in Tibetan adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A more active bone turnover status was found in Tibetan adults than in individuals from the plain areas of China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24068","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T20:16:59Z","timestamp":1635279419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of bone metabolism\u2010associated biomarkers in Tibet, China"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-5286","authenticated-orcid":false,"given":"Yutong","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Peking Union Medical 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