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Single\u2010nucleotide polymorphisms (SNPs) of the cytochrome P450 family 2 subfamily B member 6 (CYP2B6) gene are reported to be associated with HSCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the association of rs2054675, rs707265, and rs1042389 with HSCR susceptibility in southern Chinese children including 1470 HSCR patients and 1473 controls using the TaqMan SNP Genotyping Assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>rs2054675 C allele and the rs707265 G allele were risk SNPs for total colonic aganglionosis (OR = 1.82, 95% CI 1.29 ~ 2.55, <jats:italic>P<\/jats:italic>_<jats:italic>adj<\/jats:italic> &lt; 0.001 and OR = 0.68, 95% CI 0.48 ~ 0.97, <jats:italic>P<\/jats:italic>_<jats:italic>adj<\/jats:italic> = 0.034). These results suggested that CYP2B6 rs2054675 and rs707265 polymorphisms were associated with increased susceptibility to the severe HSCR subtype in southern Chinese children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that CYP2B6 rs2054675 and rs707265 polymorphisms are associated with increased susceptibility to the severe HSCR subtype in southern Chinese children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24074","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T18:08:49Z","timestamp":1636481329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Associations of <i>CYP2B6<\/i> genetic polymorphisms with Hirschsprung\u2019s disease in a southern Chinese population"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-2429","authenticated-orcid":false,"given":"Yanqing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoting","family":"Lan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxiao","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of Pediatrics Guangzhou Women and Children\u2019s Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Jinan University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Guangzhou Institute of 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