{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:50:09Z","timestamp":1770843009902,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to explore the association of long non\u2010coding RNA nuclear\u2010enriched abundant transcript 1 (lnc\u2010NEAT1) with inflammation, disease activity, treatment outcome, and its targets (microRNA [miR]\u201021 and miR\u2010125a) in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood mononuclear cells were sampled from 130 RA patients at baseline, week (W) 6, and W12, as well as from 60 healthy controls (HCs) after enrollment. Meanwhile, the expressions of lnc\u2010NEAT1, miR\u201021, and miR\u2010125a were detected by reverse transcription\u2010quantitative polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>lnc\u2010NEAT1 was elevated, but miR\u201021 and miR\u2010125a were declined in RA patients compared with HCs (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); meanwhile, lnc\u2010NEAT1 was negatively correlated with miR\u201021 and miR\u2010125a (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in RA patients. Besides, elevated lnc\u2010NEAT1 but declined miR\u201021 and miR\u2010125a were correlated with erythrocyte sedimentation rate (ESR) and C\u2010reactive protein and the 28\u2010joint Disease Activity\u2010ESR score (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in RA patients. Moreover, lnc\u2010NEAT1 was declined from baseline to W12 in RA patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Additionally, lnc\u2010NEAT1 at W12 was declined in response patients compared with non\u2010response patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), and also decreased in remission patients compared with non\u2010remission patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>lnc\u2010NEAT1 and its targets (miR\u201021 and miR\u2010125a) correlate with RA risk and disease activity, and declined lnc\u2010NEAT1 associates with better treatment outcome to some extent in RA patients, suggesting that lnc\u2010NEAT1 might be a potential biomarker to monitor disease activity and treatment outcome in RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24076","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T10:39:29Z","timestamp":1635417569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long non\u2010coding RNA NEAT1 and its targets (microRNA\u201021 and microRNA\u2010125a) in rheumatoid arthritis: Altered expression and potential to monitor disease activity and treatment outcome"],"prefix":"10.1002","volume":"35","author":[{"given":"Junfeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Sports Medicine Wuxi Traditional Chinese Medicine Hospital Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Joint Orthopedics Wuxi Traditional Chinese Medicine Hospital Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Wuxi Traditional Chinese Medicine Hospital Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Joint Orthopedics Wuxi Traditional Chinese Medicine Hospital Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2981-4764","authenticated-orcid":false,"given":"Yang","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine Wuxi Traditional Chinese Medicine Hospital Wuxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"issue":"9","key":"e_1_2_8_2_1","first-page":"626","article-title":"Rheumatoid arthritis","volume":"39","author":"Ngian GS","year":"2010","journal-title":"Aust Fam Physician"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.005"},{"key":"e_1_2_8_5_1","article-title":"Comorbidity in rheumatoid arthritis","volume":"146","author":"Turesson C","year":"2016","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530317666171114122417"},{"issue":"19","key":"e_1_2_8_7_1","first-page":"9797","article-title":"A nomogram to predict recurrence of RA patients in clinical remission within one year","volume":"24","author":"Hu XL","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022946"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23299"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23056"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00461-4"},{"issue":"5","key":"e_1_2_8_12_1","first-page":"2903","article-title":"Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome\u2010mediated polarization of macrophages","volume":"42","author":"Liu R","year":"2018","journal-title":"Int J Mol Med"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"646","article-title":"Expression of lncRNA NEAT1 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and its correlation with Th1\/Th2 balance","volume":"14","author":"Jiang Y","year":"2021","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.07.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-015-0069-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.11.017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.551681"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1509636"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.07.012"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i44.7888"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09482-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325819901239"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.04.014"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622321991705"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106992"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2018.07.044"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040880"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:10:19Z","timestamp":1693192219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/jcla.24076"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24076","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]},"assertion":[{"value":"2021-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24076"}}