{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:25Z","timestamp":1772118685840,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730003"],"award-info":[{"award-number":["81730003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore clinical indexes for management of severe\/critically ill patients with COVID\u201019, influenza A H7N9, and H1N1 pneumonia by comparing hematological and radiological characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Severe\/critically ill patients with COVID\u201019, H7N9, and H1N1 pneumonia were retrospectively enrolled. The demographic data, clinical manifestations, hematological parameters, and radiological characteristics were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, 16 cases of COVID\u201019, 10 cases of H7N9, and 13 cases of H1N1 who met severe\/critically ill criteria were included. Compared with COVID\u201019, H7N9 and H1N1\u00a0groups had more chronic diseases (80% and 92.3% vs. 25%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), higher APACHE \u2161 scores (16.00\u00a0\u00b1\u00a08.63 and 15.08\u00a0\u00b1\u00a06.24, vs. 5.50\u00a0\u00b1\u00a02.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), higher mortality rates (40% and 46.2% vs. 0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), significant lymphocytopenia (0.59\u00a0\u00b1\u00a00.31\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L and 0.56\u00a0\u00b1\u00a00.35\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L vs. 0.97\u00a0\u00b1\u00a00.33\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), and elevated neutrophil\u2010to\u2010lymphocyte ratio (NLR; 14.67\u00a0\u00b1\u00a06.10 and 14.64\u00a0\u00b1\u00a010.36 vs. 6.29\u00a0\u00b1\u00a03.72,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Compared with the H7N9\u00a0group, ground\u2010glass opacity (GGO) on chest CT was common in the COVID\u201019\u00a0group (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.028), while pleural effusion was rare (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The NLR can be used as a clinical parameter for the predication of risk stratification and outcome in COVID\u201019 and influenza A pneumonia. Manifestations of pleural effusion or GGO in chest CT may be helpful for the identification of different viral pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24100","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T12:29:17Z","timestamp":1636633757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparative study of hematological and radiological feature of severe\/critically ill patients with COVID\u201019, influenza A H7N9, and H1N1 pneumonia"],"prefix":"10.1002","volume":"35","author":[{"given":"Jindan","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou China"},{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Biology and Basic Medical Sciences Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Infectious Diseases Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leisi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9044-024X","authenticated-orcid":false,"given":"Jianhong","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China"},{"name":"Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Collaborative Innovation Center of Hematology Key Laboratory of Thrombosis and Hemostasis of Ministry of Health Suzhou 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