{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:29:11Z","timestamp":1787934551741,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970735"],"award-info":[{"award-number":["81970735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune thyroid disease (AITD) mainly includes Graves\u2019 disease (GD) and Hashimoto's thyroiditis (HT), which is caused by individual genetics, autoimmune dysfunction, and a variety of external environmental factors. Interleukin (IL)\u201038 is involved in a wide range of autoimmune diseases, but little is known about IL\u201038 expression in AITD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty patients with GD, 50 with HT, and 50\u00a0healthy controls (HC) were enrolled in this study. Basic information of the participants was obtained through a physical examination. Immunological data were obtained by an automatic chemiluminescence immunoanalyzer. C\u2010reactive protein (CRP) concentrations and the white blood cell count were measured. Serum IL\u201038\u00a0levels were determined by an enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum IL\u201038\u00a0levels were significantly lower in the GD and HT groups than in the HC group (both<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Serum CRP concentrations were significantly lower in the HT group than in the HC group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Receiver operating characteristic curve analysis showed that the area under the curve was 0.7736 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) for IL\u201038 and 0.7972 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) for IL\u201038 combined with CRP in the GD group. In the HT group, the area under the curve was 0.7276 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) for IL\u201038 and 0.7300 for IL\u201038 combined with CRP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that serum IL\u201038\u00a0level is a potential new diagnostic biomarker in patients with GD and HT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24101","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T06:15:41Z","timestamp":1637388941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Low serum interleukin\u201038 levels in patients with Graves\u2019 disease and Hashimoto\u2019s thyroiditis"],"prefix":"10.1002","volume":"36","author":[{"given":"Jialu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Affiliated Lihuili Hospital, Ningbo University Ningbo China"},{"name":"Department of Immunology, Zhejiang Key Laboratory of Pathophysiology Ningbo University School of Medicine Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zhejiang Key Laboratory of Pathophysiology Ningbo University School of Medicine Ningbo China"},{"name":"Department of Endocrinology, The Affiliated Hospital of Medical School Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zhejiang Key Laboratory of Pathophysiology Ningbo University School of Medicine Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zhejiang Key Laboratory of 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