{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:58Z","timestamp":1786977898577,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["OG\u201096139"],"award-info":[{"award-number":["OG\u201096139"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      is the most common and virulent genus\n                      <jats:italic>Candida<\/jats:italic>\n                      . Detection of virulence factors in this species plays an important role in the better understanding of pathogenesis and antifungal treatment. Molecular typing investigations are important in the epidemiological interpretation of infection. This study aimed to evaluate extracellular enzyme activity and genotyping of\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      species isolated from vulvovaginal samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and three vaginal\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      isolates were tested for esterase, phospholipase, proteinase, and hemolysin activities by specific media. Besides, the DNA of\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      isolates was extracted and amplified for ABC genotyping.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The highest enzyme production of\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      isolates was for proteinase (97.1%) and esterase (95.2%), whereas 59.2% of\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      isolates were negative for hemolysin secretion. Genotype C (83.5%) was the most frequent genotype followed by genotype B (12.6%) and genotype A (3.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      It is concluded that genotype C was the predominant genotype in all examined vulvovaginal\n                      <jats:italic>C<\/jats:italic>\n                      .\n                      <jats:italic>albicans<\/jats:italic>\n                      isolates. Also, there was a significant difference between enzyme production in each genotype (except for proteinase).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24117","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T16:08:17Z","timestamp":1638029297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["ABC typing and extracellular enzyme production of\n                    <i>Candida albicans<\/i>\n                    isolated from\n                    <i>Candida<\/i>\n                    vulvovaginitis"],"prefix":"10.1002","volume":"36","author":[{"given":"Maral","family":"Gharaghani","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Department of Medical Mycology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbubeh","family":"Shabanzadeh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Department of Medical Mycology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadis","family":"Jafarian","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Department of Medical Mycology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-2082","authenticated-orcid":false,"given":"Ali","family":"Zarei Mahmoudabadi","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Research Center Health Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Department of Medical Mycology School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568005043341046"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2010.2744"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.12804"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2016.01.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762012000200008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.2.417-421.1999"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"12","article-title":"Genotyping of Candida albicans isolated from animals using 25S ribosomal DNA and ALT repeats polymorphism in repetitive sequence","volume":"4","author":"Dalvand A","year":"2018","journal-title":"Curr Med Mycol"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"1","article-title":"Candida species distribution, genotyping and virulence factors of Candida albicans isolated from the oral cavity of kidney transplant recipients of two geographic regions of Brazil","volume":"14","author":"Silva\u2010Rocha WP","year":"2014","journal-title":"BMC Oral Health"},{"issue":"25","key":"e_1_2_9_10_1","first-page":"4406","article-title":"Genotyping and antifungal susceptibility of Candida albicans clinical isolates from Yangzhou region in China","volume":"5","author":"Zhu X","year":"2011","journal-title":"Afr J Microbiol Res"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2005.01165.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.3.400-428.2003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.20162"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"e89815","article-title":"Prevalence of vulvovaginal candidiasis in Ahvaz, southwest Iran: a semi\u2010large scale study","volume":"12","author":"Kiasat N","year":"2019","journal-title":"Jundishapur J Microbiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2144\/000113672"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.41446"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00362178285380031"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.103592"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903501689"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00041-07"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23826"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105173"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47303-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.01057.x"},{"issue":"4","key":"e_1_2_9_25_1","first-page":"169","article-title":"Phospholipase activity of Candida albicans isolated from vagina and urine samples","volume":"3","author":"Zarei Mahmoudabadi A","year":"2010","journal-title":"Jundishapur J Microbiol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242013000600007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2017.01.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12206"},{"issue":"2","key":"e_1_2_9_29_1","first-page":"101","article-title":"Esterase activity of Candida species isolated from immunocompromised hosts","volume":"23","author":"Kumar C","year":"2006","journal-title":"Rev Iberoam De Micol"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:22:30Z","timestamp":1693182150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,27]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jcla.24117"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24117","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,27]]},"assertion":[{"value":"2021-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24117"}}