{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:45:47Z","timestamp":1786769147882,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670721"],"award-info":[{"award-number":["81670721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thyroid hormone autoantibody (THAb) is a common antibody in autoimmune disease and can interfere with the detection of thyroid hormone (TH). There was no research reporting the prevalence of THAb in Chinese and the rate of THAb interfering with TH detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected 114 patients with autoimmune thyroid disease (AITD) (Hashimoto's thyroiditis, 57 cases; Graves\u2019 disease, 57 cases), 106 patients with nonthyroid autoimmune diseases (NTAID), and 120 healthy subjects. According to the presence or absence of thyroid antibodies, patients with NTAID were divided into two groups: NTAID\u2010AITD and NTAID groups. Radioimmunoprecipitation technique was used to detect THAb in all subjects. TH was detected on Abbot and Roche platforms in patients with positive THAb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of THAb was 22.8% in Hashimoto's thyroiditis and 45.6% in Graves\u2019 disease. The prevalence of THAb in AITD group was lower than that in NTAID or NTAID\u2010AITD groups (34.2% vs. 61.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.014; 34.2% vs. 71.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Among total 98 patients with positive THAb, TH levels of 9 patients were falsely elevated (9.18%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of THAb in AITD patients was lower than that in NTAID patients. Although THAb had a high frequency in various autoimmune diseases, the prevalence of THAb interfering with TH detection was only 9.18%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24124","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T09:44:37Z","timestamp":1638351877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High prevalence of thyroid hormone autoantibody and low rate of thyroid hormone detection interference"],"prefix":"10.1002","volume":"36","author":[{"given":"Jiajia","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Endocrinology People's Hospital of Xiangxi Tujia and Miao Autonomous Prefecture  Xiangxi Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Shandong Provincial Hospital Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The first affiliated Hospital of Bengbu Medical College  Bengbu Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjia","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-4793","authenticated-orcid":false,"given":"Haiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Shandong Provincial Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","first-page":"4217","article-title":"Thyroid hormone autoantibodies elicited by diagnostic fine needle biopsy","volume":"82","author":"Benvenga 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