{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:41Z","timestamp":1786978001689,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cord\u2010blood and heel\u2010prick TSH levels are essential in diagnosing and preventing the serious complications of congenital hypothyroidism, which mainly include intellectual disability. The study aimed to compare between cord\u2010blood and heel\u2010prick TSH sensitivity and specificity in detecting congenital hypothyroidism (CH) among newborn screened babies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study included 21,012 newborn screened babies for congenital hypothyroidism starting from September 2013 until March 2019. Both cord\u2010blood and heel\u2010prick TSH were collected from each newborn. Heel prick and cord\u2010blood TSH cutoff values of &gt;21 \u03bcU\/ml and &gt;30\u00a0mIU\/L respectively were considered positive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of the total screened newborns, 12 were confirmed for having primary congenital hypothyroidism. Nine cases were positive for cord\u2010blood TSH (Sensitivity 75%, specificity 99.9%, and a recall rate of 0.004%), while 139 cases were positive for heel\u2010prick blood TSH (Sensitivity of 100%, specificity of 99.3%, and a recall rate of 0.60%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For the screening of CH, heel prick is considered a superior method, but cord blood remains a practical option due to its cost\u2010effectiveness, immediate action, and lower recall rate. Therefore, whenever recall is difficult and\/or early discharge is the practice, cord blood is an alternative method to heel prick but not with cases of prematurity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24149","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T07:53:51Z","timestamp":1638518031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic comparison between cord blood and filter paper for the screening of congenital hypothyroidism"],"prefix":"10.1002","volume":"36","author":[{"given":"Seham","family":"Alameer","sequence":"first","affiliation":[{"name":"Department of Pediatric Ministry of the National Guard\u2010Health Affairs King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Althobaiti","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences King Abdulaziz Medical City Ministry of National Guard Health Affairs Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud","family":"Alshaikh","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences King Abdulaziz Medical City Ministry of National Guard Health Affairs Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshari","family":"Turjoman","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Prince Mohammad ben Abdul\u2010Aziz Hospital Ministry of National 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