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This study aims to evaluate the pathogens\u2019 coinfection prevalence among COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In order to find all of the relevant articles, we used systematic search approach. Research\u2010based databases including PubMed, Web of Science, Embase, and Scopus, without language restrictions, were searched to identify the relevant bacterial, fungal, and viral coinfections among COVID\u201019 cases from December 1, 2019, to August 23, 2021. In order to dig deeper, other scientific repositories such as Medrxiv were probed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13,023\u00a0studies were found through systematic search. After thorough analysis, only 64\u00a0studies with 61,547 patients were included in the study. The most common causative agents of coinfection among COVID\u201019 patients were bacteria (pooled prevalence: 20.97%; 95% CI: 15.95\u201326.46; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 99.9%) and less frequent were virus coinfections (pooled prevalence: 12.58%; 95% CI: 7.31\u201318.96; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 98.7%). The pooled prevalence of fungal coinfections was also 12.60% (95% CI: 7.84\u201317.36; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>: 98.3%). Meta\u2010regression analysis showed that the age sample size and WHO geographic region did not influenced heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a high prevalence of pathogenic microorganism coinfection among COVID\u201019 patients. Because of this rate of coinfection empirical use of antibacterial, antifungal, and antiviral treatment are advisable specifically at the early stage of COVID\u201019 infection. We also suggest running simultaneously diagnostic tests to identify other microbiological agents\u2019 coinfection with SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24151","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T14:02:11Z","timestamp":1638367331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Worldwide prevalence of microbial agents\u2019 coinfection among COVID\u201019 patients: A comprehensive updated systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Reza","family":"Pakzad","sequence":"first","affiliation":[{"name":"Department of Epidemiology Faculty of Health Ilam University Medical Sciences Ilam Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooneh","family":"Malekifar","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health 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