{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:30:13Z","timestamp":1774063813483,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>JNK pathway\u2010associated phosphatase (JKAP) involves in the regulation of inflammation, immunity, and lung injury. The current study aimed to investigate correlation of JKAP with Th1, Th17 cells, acute exacerbation risk, and disease severity in chronic obstructive pulmonary disease (COPD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 45\u00a0stable COPD (SCOPD) patients, 45 acute exacerbation COPD (AECOPD) patients, and 45 controls were enrolled. Serum was collected for JKAP, interferon\u2010gamma (IFN\u2010\u03b3) (Th1 cytokine), and interleukin 17 (IL\u201017) (Th17 cytokine) detection. Besides, peripheral blood mononuclear cell from COPD patients was collected for evaluating Th1 and Th17 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>JKAP was highest in controls followed by SCOPD patients and lowest in AECOPD patients (median: 105.673 vs. 75.374 vs. 41.807\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Meanwhile, receiver operating characteristic (ROC) curves revealed that JKAP differentiated the AECOPD patients from the controls (area under curve (AUC): 0.910 (95% confidence interval (CI): 0.849\u20130.970)) and AECOPD patients from SCOPD patients (AUC: 0.726 (95% CI: 0.622\u20130.830)). Moreover, JKAP positively correlated with FEV<jats:sub>1<\/jats:sub> (%predicted) in AECOPD patients (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.347 <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019). Additionally, JKAP was negatively correlated with the GOLD stage in AECOPD patients (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.344, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and SCOPD patients (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.357, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016). Whereas, JKAP was not associated with other clinical features (all <jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). Besides, JKAP was negatively linked with Th17 cells (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.378, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010), IFN\u2010\u03b3 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.358, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016), IL\u201017 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.414, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) in AECOPD patients and Th17 cells (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.342, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.022), IL\u201017 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.299, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.046) in SCOPD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Downregulated JKAP correlates with Th17 cells, higher acute exacerbation risk, and severity in COPD patients, indicating its underlying potency as a biomarker for COPD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24153","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:48:20Z","timestamp":1639727300000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating JNK pathway\u2010associated phosphatase: A novel biomarker correlates with Th17 cells, acute exacerbation risk, and severity in chronic obstructive pulmonary disease patients"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1335-0491","authenticated-orcid":false,"given":"Wei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center Beijing Bo\u2019ai Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center Beijing Bo\u2019ai Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center Beijing Bo\u2019ai Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Capital Medical University School of Rehabilitation Medicine China Rehabilitation Research Center Beijing Bo\u2019ai Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12780"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S106160"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S145253"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-036060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2019-214484"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12522"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01448-2018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246157"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200453200"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.060186"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00781"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51420"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22945"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11419"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1037"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00110-2019"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2019.08.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0218PP"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100408200"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111433"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1416"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4618"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.253.19"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:24:07Z","timestamp":1693196647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jcla.24153"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24153","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]},"assertion":[{"value":"2021-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24153"}}