{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:52:56Z","timestamp":1781088776336,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>MicroRNA (miR)\u2010146a and miR\u2010146b regulate autoimmunity, inflammation, and keratinocytes proliferation to engage in psoriasis pathology. The current study aimed to investigate their correlation with disease risk and clinical features, and the linkage of their longitudinal changes with clinical response to etanercept in psoriasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma samples were collected from 84 moderate\u2010to\u2010severe psoriasis patients who underwent etanercept treatment (at baseline (M0), 1\u00a0month (M1), 3\u00a0months (M3), and 6\u00a0months (M6)), 80 disease controls and 80\u00a0health controls (both after enrollment); afterward, miR\u2010146a and miR\u2010146b expressions were detected by RT\u2010qPCR. Furthermore, PASI75 and PASI90 responses were assessed in psoriasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both miR\u2010146a and miR\u2010146b were decreased in psoriasis patients compared with disease controls and health controls (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), which also distinguished psoriasis patients from disease controls and health controls by receiver\u2010operating characteristic analyses. Furthermore, miR\u2010146a positively correlated with miR\u2010146b in psoriasis patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and disease controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) but not in healthy controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.062). In psoriasis patients, miR\u2010146a negatively related to psoriatic body surface area (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) and PASI score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003); miR\u2010146b negatively linked with PASI score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.020). At M1, M3, and M6 after etanercept treatment, PASI75 response rate was 14.3%, 32.1%, and 69.0%, respectively; PASI90 response rate was 1.2%, 17.9%, and 36.9%, respectively. During etanercept treatment, both miR\u2010146a and miR\u2010146b elevated gradually over time and their longitude increments were associated with PASI75 response (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MiR\u2010146a and miR\u2010146b might serve as indicators for optimizing etanercept application and improving treatment outcomes in psoriasis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24198","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T06:39:10Z","timestamp":1640414350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["MicroRNA\u2010146a and microRNA\u2010146b deficiency correlates with exacerbated disease activity, and their longitude increment relates to etanercept response in psoriasis patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Hui","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Dermatology Taikang Tongji (Wuhan) Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taikang Tongji (Wuhan) Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taikang Tongji (Wuhan) Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taikang Tongji (Wuhan) Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-3401","authenticated-orcid":false,"given":"Hongbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taikang Tongji (Wuhan) Hospital Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_8_3_1","volume-title":"Psoriasis","author":"Nair PA","year":"2021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.12788\/cutis.0309"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15840"},{"key":"e_1_2_8_6_1","first-page":"143","article-title":"Psychopathological disorders as comorbidity in patients with psoriasis (Review)","volume":"301","author":"Bolotna L","year":"2020","journal-title":"Georgian Med 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