{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:38:26Z","timestamp":1785764306507,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dual specificity phosphatase 22 (DUSP22) plays an important role in the regulation of immune and inflammation, but its correlation with clinical features and treatment outcome in psoriasis patients is still unclear. This study was to investigate the longitudinal change of DUSP22 with time, as well as its association with disease activity and treatment response in psoriasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 120\u00a0psoriasis patients, 50 patients with other skin inflammations as disease controls (DCs), and 50\u00a0health controls (HCs) were recruited. Serum samples were collected from psoriasis patients at baseline, month (M)1, M3, and M6 after initiation of etanercept\u2010based treatment as well as from DCs and HCs after enrollment to assess DUSP22\u00a0level by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DUSP22 was lower in psoriasis patients than in HCs and DCs (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Besides, in psoriasis patients, DUSP22 was associated with lower psoriasis area severity index (PASI) score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and systemic biological treatment history (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.023), but not with other demographics, disease characteristics, or treatment history (all <jats:italic>p<\/jats:italic>&gt;0.05). In addition, DUSP22 was increased with time (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in total patients. Moreover, DUSP22 at M3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and M6 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) was higher in response patients than in non\u2010response patients evaluated by PASI 75. Additionally, DUSP22 at M3 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and M6 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) was also increased in response patients compared with non\u2010response patients evaluated by PASI 90.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DUSP22 decreases and negatively correlates with disease activity, while its longitudinal elevation with time reflects satisfactory treatment response in psoriasis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24199","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T06:40:02Z","timestamp":1641019202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dual specificity phosphatase 22 relates to skin lesion degree and biologics history, while its longitudinal elevation during treatment reflects better outcome in psoriasis patients"],"prefix":"10.1002","volume":"36","author":[{"given":"Cailing","family":"E","sequence":"first","affiliation":[{"name":"Department of Dermatology Renmin Hospital, Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Renmin Hospital, Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Renmin Hospital, Hubei University of Medicine Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zudong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Renmin Hospital, Hubei University of Medicine Shiyan 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