{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:12:18Z","timestamp":1777777938703,"version":"3.51.4"},"reference-count":78,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary open\u2010angle glaucoma (POAG) is the commonest form of glaucoma which is estimated to cause bilaterally blind within 11.1\u00a0million people by 2020. Therefore, the primary objectives of this study were to investigate the clinical significance of single\u2010nucleotide polymorphisms (SNPs) in the lncRNAs MALAT1 and ANRIL in a Chinese Han POAG cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and forty\u2010six glaucoma patients and 263\u00a0healthy controls were recruited, and totally 14 SNPs in MALAT1 and ANRIL were genotyped between the two populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MALAT1 SNPs rs619586 (A&gt;G), rs3200401 (C&gt;T), and rs664589 (C&gt;G) were associated with POAG risk, and the ANRIL SNPs rs2383207 (A&gt;G), rs564398 (A&gt;G), rs2157719 (A&gt;G), rs7865618 (G&gt;A), and rs4977574 (A&gt;G) were associated with POAG (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The MALAT1\u00a0haplotypes ACG and ATC, comprised rs619586, rs3200401, and rs664589, increased POAG risk, and the ANRIL haplotype AAGAA, made up of rs2383207, rs7865618, rs4977574, rs564398, and rs2157719, show a significantly increased risk of POAG. In addition, rs619586 (A&gt;G) of MALAT1 and rs564398\/rs2157719 of ANRIL were associated with a smaller vertical cup\u2010to\u2010disc ratio, while rs619586 of MALAT1 and rs2383207\/rs4977574 of ANRIL were associated with higher intraocular pressure in the POAG population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single\u2010nucleotide polymorphisms and haplotypes in ANRIL and MALAT1 were associated with POAG onset in our study population, which provide more possibilities to POAG diagnosis and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24215","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T08:40:05Z","timestamp":1642149605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Significance of the lncRNAs MALAT1 and ANRIL in occurrence and development of 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