{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:34:45Z","timestamp":1784669685413,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated serum ferritin levels (SFLs) was previously reported to be related with hepatic histologic severity and advanced liver fibrosis among non\u2010alcoholic fatty liver disease (NAFLD) patients. However, whether NAFLD influences SFLs remains uncertain and needs more clinical evidences. This study explored the differences of SFLs in US adults with or without NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study of 3689 participants aged 18\u201380\u00a0years using the National Health and Nutrition Examination Survey (NHANES) 2017\u20132018 cycle. NAFLD status was confirmed based on controlled attenuation parameter (CAP) values \u2265274\u00a0dB\/m through vibration controlled and transient elastography (VCTE). We performed weighted multivariable logistic regression models to evaluate the associations between NAFLD and SFLs in different age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a positive association between NAFLD and SFLs in all three models (model 1:\u03b2\u00a0=\u00a023.07, 95% CI: 10.32, 35.81; model 2:\u03b2\u00a0=\u00a023.68, 95% CI: 10.86, 36.50; model 3:\u03b2\u00a0=\u00a013.86, 95% CI: 0.29, 27.43). After adjusting for the covariates, this positive association persisted in females (\u03b2\u00a0=\u00a016.22, 95% CI: 2.81, 29.62). Further, relationships between NAFLD and SFLs were significantly different in various age groups. In the subgroup stratified by gender, their associations further differed. In males, the positive association was more prominent in 50\u201364\u00a0age group (\u03b2\u00a0=\u00a070.89, 95% CI: 25.14, 116.64). In females, this positive association was more prominent in 18\u201334\u00a0age group (\u03b2\u00a0=\u00a020.72, 95% CI: 7.45, 33.99). However, no correlations between severe steatosis, significant fibrosis, advanced fibrosis, cirrhosis, and SFLs in adults with NAFLD were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated that US adults suffered with NAFLD had significantly higher SFLs compared with their counterparts in non\u2010NAFLD group. Moreover, the associations between NAFLD and SFLs further differed by age and gender.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24225","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T07:39:54Z","timestamp":1641627594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The association between non\u2010alcoholic fatty liver disease and serum ferritin levels in American adults"],"prefix":"10.1002","volume":"36","author":[{"given":"Naibin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Ningbo First Hospital Ningbo Hospital of Zhejiang University Ningbo China"},{"name":"NAFLD Research Center Department of Hepatology Ningbo First Hospital Ningbo Hospital of Zhejiang University Ningbo China"},{"name":"NAFLD Research Center Department of Hepatology and Infectious Diseases The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Nanshan College Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Tai'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-5862","authenticated-orcid":false,"given":"Mingqin","family":"Lu","sequence":"additional","affiliation":[{"name":"NAFLD Research Center Department of Hepatology and Infectious Diseases The First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00523-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_10_4_1","first-page":"S11","article-title":"Natural history of nonalcoholic steatohepatitis","volume":"40","author":"Liou I","year":"2006","journal-title":"J Clin Gastroenterol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1503519"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.06.048"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14096"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02488.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-9892-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0613-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S268592"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.06.048"},{"key":"e_1_2_10_14_1","unstructured":"Cfdcap.National Health and Nutrition Examination Survey (NHANES). 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