{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:36:26Z","timestamp":1791041786148,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Long noncoding RNA nuclear enriched abundant transcript 1 (lnc\u2010NEAT1) and its target microRNA\u2010125a (miR\u2010125a) are reported to regulate immune and inflammation process in allergic rhinitis (AR). Hence, this study intended to investigate the correlation between lnc\u2010NEAT1 and miR\u2010125a expressions, as well as their clinical values in pediatric AR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood mononuclear cell samples from 80 pediatric AR patients, 40 disease controls (DCs), and 40\u00a0healthy controls (HCs) were collected to detect lnc\u2010NEAT1 and miR\u2010125a expressions by reverse transcription\u2010quantitative polymerase chain reaction. For pediatric AR patients only, serum interferon\u2010gamma (IFN\u2010\u03b3) and interleukin (IL)\u201010 were measured by enzyme linked immunosorbent assay; meanwhile, T helper (Th) 1 and Th2 cells in CD4<jats:sup>+<\/jats:sup> T cells were analyzed by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lnc\u2010NEAT1 was overexpressed, while miR\u2010125a downregulated in pediatric AR patients compared to DCs and HCs (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, lnc\u2010NEAT1 expression negatively correlated with miR\u2010125a expression in pediatric AR patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), but not in DCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.226) or HCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.237). Furthermore, in pediatric AR patients, lnc\u2010NEAT1 expression positively associated with TNSS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), sneezing score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), and congestion score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008); miR\u2010125a expression was negatively related to TNSS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), itching score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.040), and sneezing score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005). Additionally, lnc\u2010NEAT1 expression positively, while miR\u2010125a expression negatively correlated with Th2 cells and IL\u201010 (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), but they were not correlated with Th1 cells or IFN\u2010\u03b3 in pediatric AR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating lnc\u2010NEAT1 and miR\u2010125a are aberrantly expressed and linked with Th2 cells and symptom severity in pediatric allergic rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24235","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T11:41:20Z","timestamp":1642851680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Aberrant expressions of circulating lncRNA NEAT1 and microRNA\u2010125a are linked with Th2 cells and symptom severity in pediatric allergic 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