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Lipoarabinomannan (LAM) provides an opportunity for TB diagnosis, and urine LAM detection seems to have a promising and widely applicable prospect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design or methods<\/jats:title><jats:p>Four databases were systematically searched for eligible studies, and the quality of the studies was evaluated using the quality assessment of diagnostic accuracy studies\u20102 (QUADAS\u20102). Graphs and tables were created to show sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), the area under the curve (AUC), and so on.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the included 67\u00a0studies, the pooled sensitivity of urine LAM was 48% and specificity was 89%. In the subgroup analyses, the FujiLAM test had higher sensitivity (69%) and specificity (92%). Furthermore, among patients infected with human immunodeficiency virus (HIV), 50% of TB patients were diagnosed using a urine LAM test. Besides, the CD4+ cell count was inversely proportional to the sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Urine LAM is a promising diagnostic test for TB, particularly using the FujiLAM in HIV\u2010infected adults whose CD4+ cell count is \u2264100 per \u03bcl. Besides, the urine LAM test shows various sensitivities and specificities in different subgroups in terms of age, HIV infection status, CD4+ cell count, and testing method.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24238","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T17:34:11Z","timestamp":1642354451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic value of Lipoarabinomannan antigen for detecting <i>Mycobacterium tuberculosis<\/i> in adults and children with or without HIV infection"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-2111","authenticated-orcid":false,"given":"Xin","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China"},{"name":"Department of Pediatrics The Pediatrics School of 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