{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:30:55Z","timestamp":1787884255422,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is known that inflammatory responses play an important role in the pathophysiology of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to examine the role of kynurenine (KYN) metabolism on the severity of COVID\u201019 disease AQ5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>Seventy COVID\u201019 patients of varying severity and 30 controls were included in the study. In addition to the classical laboratory parameters, KYN, tryptophan (TRP), kynurenic acid (KYNA), 3 hydroxykynurenine (3OHKYN), quinolinic acid (QA), and picolinic acid (PA) were measured with mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TRP, KYN, KYN:TRP ratio, KYNA, 3OHKYN, PA, and QA results were found to be significantly different in COVID\u201019 patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for all). The KYN:TRP ratio and PA of severe COVID\u201019 patients was statistically higher than that of mild\u2010moderate COVID\u201019 patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for all). When results were examined, statistically significant correlations with KYN:TRP ratio, IL\u20106, ferritin, and procalcitonin were only found in COVID\u201019 patients. ROC analysis indicated that highest AUC values were obtained by KYN:TRP ratio and PA (0.751 vs 0.742). In determining the severity of COVID\u201019 disease, the odd ratios (and confidence intervals) of KYN:TRP ratio and PA levels that were adjusted according to age, gender, and comorbidity were determined to be 1.44 (1.1\u20131.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) and 1.06 (1.02\u20131.11, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.006), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion &amp; Conclusion<\/jats:title><jats:p>According to the results of this study, KYN metabolites play a role in the pathophysiology of COVID\u201019, especially KYN:TRP ratio and PA could be markers for identification of severe COVID\u201019 cases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24257","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T17:18:41Z","timestamp":1643476721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Kynurenine pathway in Coronavirus disease (COVID\u201019): Potential role in prognosis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-7226","authenticated-orcid":false,"given":"Murat","family":"Cihan","sequence":"first","affiliation":[{"name":"Clinical Laboratory Ordu University Training and Research Hospital Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3078-999X","authenticated-orcid":false,"given":"\u00d6zlem","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-7030","authenticated-orcid":false,"given":"Ceyhan","family":"Ceran Serdar","sequence":"additional","affiliation":[{"name":"Medical Biology and Genetics Faculty of Medicine Ankara Medipol University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-9838","authenticated-orcid":false,"given":"Arzu","family":"Altun\u00e7eki\u00e7 Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Ordu University School of Medicine Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-4508","authenticated-orcid":false,"given":"Celali","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Ordu University School of Medicine Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-748X","authenticated-orcid":false,"given":"Muhittin A.","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Ac\u0131badem Mekmet Ali Aydinlar University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.08.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02415.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-2-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.166042"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2741\/4363"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00058"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2016.01.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1918215117"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9090249"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-201042"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4595"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12677"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.04.009"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.02.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2020.113246"},{"key":"e_1_2_7_22_1","unstructured":"Clinical and Laboratory Standards Institute (CLSI).Mass spectrometry in the clinical laboratory: general principles and guidance; 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