{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:36:27Z","timestamp":1791041787221,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Long non\u2010coding RNA plasmacytoma variant translocation 1 (lnc\u2010PVT1) exacerbates inflammation and induces T helper (Th) 1\/Th2 imbalance in allergic diseases, but its clinical role in allergic rhinitis (AR) remains unclear. Hence, we conducted this study to compare lnc\u2010PVT1 expression among AR children, disease controls (DCs), and health controls (HCs), aiming to investigate its clinical application in AR children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty AR children, 30 DCs, and 30 HCs were enrolled in the study, and then, their lnc\u2010PVT1 expression in peripheral blood mononuclear cell was detected. Serum interferon\u2010gamma (IFN\u2010\u03b3), interleukin 10 (IL\u201010), Th1, and Th2 cells in AR children were also analyzed. Besides, lnc\u2010PVT1 was also detected at Week (W)4 after treatment in AR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lnc\u2010PVT1 was upregulated in AR children compared with DCs and HCs (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Lnc\u2010PVT1 was positively related to nasal rhinorrhea score, itching score, congestion score, and total nasal symptom score (TNSS) in AR children (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.050), instead of sneezing score (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.115). Lnc\u2010PVT1 negatively associated with Th1 cells in AR children (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028) also exhibited a negative correlation trend with IFN\u2010\u03b3 (but without statistical significance) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.065). Differently, lnc\u2010PVT1 was positively related to Th2 cells (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and IL\u201010 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) in AR children. Besides, lnc\u2010PVT1 and TNSS were reduced at W4 after treatment in AR children (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001); notably, lnc\u2010PVT1 expression decline was correlated with TNSS decline during treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lnc\u2010PVT1 works as a biomarker, whose aberrant expression is related to disease severity, Th1\/Th2 imbalance, and its decrement can reflect treatment outcome in AR children.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24281","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T11:23:54Z","timestamp":1646997834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant expression of long non\u2010coding RNA PVT1 in allergic rhinitis children: Correlation with disease risk, symptoms, and Th1\/Th2 imbalance"],"prefix":"10.1002","volume":"36","author":[{"given":"Yujun","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Second People\u2019s Hospital of Liaocheng The Second Hospital of Liaocheng Affiliated to Shandong First Medical University  Linqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiac Ultrasound The Second People\u2019s Hospital of Liaocheng The Second Hospital of Liaocheng Affiliated to Shandong First Medical University  Linqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second People\u2019s Hospital of Liaocheng The Second Hospital of Liaocheng Affiliated to Shandong First Medical University  Linqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second People\u2019s Hospital of Liaocheng The Second Hospital of Liaocheng Affiliated to Shandong First Medical University  Linqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-6224","authenticated-orcid":false,"given":"Zengzhi","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second People\u2019s Hospital of Liaocheng The Second Hospital of Liaocheng Affiliated to Shandong First Medical University  Linqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00227-0"},{"key":"e_1_2_8_3_1","volume-title":"Allergic rhinitis","author":"Akhouri S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2019.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2019.11.2.156"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2014.6.2.105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-019-0843-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15367.1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.03.028"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1808622"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.17116\/otorino20208501174"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073_c"},{"issue":"2","key":"e_1_2_8_14_1","first-page":"116","article-title":"Subspecialty Group of Rhinology EBoCJoOH, Neck S, Subspecialty Group of R, Pediatrics DoOH, Neck Surgery CMA, Editorial Board of Chinese Journal of P. 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