{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:45:17Z","timestamp":1784954717549,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Study of the molecular biological characteristics of chronic neutrophilic leukemia complicated with plasma cell disorder (CNL\u2010PCD) and lymphocytic proliferative disease (CNL\u2010LPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of a patient with chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance (CNL\u2010MGUS) in our hospital were reviewed, and the Chinese and\/or English literature about CNL\u2010PCD and CNL\u2010LPD in PubMed and the Chinese database CNKI in the past 10\u00a0years was searched to analyze the molecular biological characteristics of this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 73\u2010year\u2010old male had persistent leukocytosis for 18\u00a0months. The white blood cell count was 46.77\u00a0\u00d7\u00a0109\/L and primarily composed of mature neutrophils; hemoglobin: 77\u00a0g\/L; platelet count: 189\u00a0\u00d7\u00a0109\/L. Serum immunofixation electrophoresis showed IgG\u2010\u03bb monoclonal M protein. A CT scan showed splenomegaly. Next\u2010generation sequencing (NGS) showed that CSF3R T618I, ASXL1 and RUNX1\u00a0mutations were positive. It was diagnosed as CNL\u2010MGUS. We summarized 10 cases of CNL\u2010PCD and 1 case of CNL\u2010LPD who underwent genetic mutation detection reported in the literature. The CSF3R mutational frequency (7\/11, 63.6%) was lower than that of isolated CNL. The ASXL1\u00a0mutations were all positive (3\/3), which may represent a poor prognostic factor. The SETBP1\u00a0mutation may promote the progression of CNL\u2010PCD. We also found JAK2, RUNX1, NRAS, etc. in CNL\u2010PCD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic neutrophilic leukemia may be more inclined to coexist with plasma cell disorder. The CSF3R mutation in CNL\u2010PCD is still the most common mutated gene compared with isolated CNL. Mutations in SETBP1 and ASXL1\u00a0may be poor prognostic factors for CNL\u2010PCD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24287","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T09:01:40Z","timestamp":1645002100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic neutrophilic leukemia complicated with monoclonal gammopathy of undetermined significance: A case report and literature review"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-5812","authenticated-orcid":false,"given":"Jia\u2010Pei","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Yangzhou University Yangzhou University Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jia","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology 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