{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:50:00Z","timestamp":1792075800942,"version":"4.4.0"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preeclampsia (PE) is a pregnancy\u2010related illness characterized by high blood pressure (BP) and proteinuria after the 20th gestational week (GW). Platelet (PLT) parameter changes are the common hematological abnormalities observed in PE patients. The main aim of this study was to assess the role of PLT parameters for PE diagnosis among pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comparative cross\u2010sectional study was conducted at the University of Gondar Specialized Hospital. A total of 126 pregnant women (63 normotensive [NT] and 63 PE) were recruited using a convenient sampling method. Three milliliter blood was collected from each participant, and PLT parameters were determined using Sysmex XS\u2010500i analyzer. An independent t\u2010test supplemented with receiver\u2010operating characteristics (ROC) were used for comparisons and diagnostic value of PLT parameters between the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Platelet count (PC) was significantly lower in the PE group compared to that in the NT group, whereas mean platelet volume (MPV), platelet large cell ratio (P\u2010LCR), and platelet distribution width (PDW) were significantly higher in PE. MPV had the largest area under the curve (AUC) [0.91: 95% CI; 0.85\u20130.96] followed by PC [0.79: 95% CI; 0.72\u20130.87]. MPV can differentiate PE patients from NT pregnant women at cut\u2010off value \u226512.10\u00a0fl (84.1% sensitivity and 87.3% specificity) while PC can indicate PE at a cut\u2010off value \u2264176.5\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L (65.1% sensitivity and 87.3% specificity).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A decreased PC and an increased MPV, P\u2010LCR, and PDW can be used as a simple, cost\u2010effective, quick, and reliable method of PE screening. Of them, MPV is the best indicator of PE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24305","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T20:40:19Z","timestamp":1645735219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-921X","authenticated-orcid":false,"given":"Muluken","family":"Walle","sequence":"first","affiliation":[{"name":"Department of Medical laboratory science College of Medicine and Health Sciences Jigjiga University  Jigjiga Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikir","family":"Asrie","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yemataw","family":"Gelaw","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zegeye","family":"Getaneh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunohematology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of Gondar  Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"90","article-title":"Platelets in pregnancy","volume":"5","author":"Juan P","year":"2011","journal-title":"Journal of Prenatal Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12758"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/781857"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","unstructured":"DrelichD BrayP.The traditional role of platelets in hemostasis. The non\u2010thrombotic role of platelets in health and disease. IntechOpen.2015.","DOI":"10.5772\/60595"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2016.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.05.004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225536"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2015.1060244"},{"key":"e_1_2_11_10_1","article-title":"Pathogenesis","author":"Karumanchi SA","year":"2019","journal-title":"UpTuDate"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"147","article-title":"Evaluation of platelet indices and their significance in preeclampsia","volume":"12","author":"Ammar K","year":"2014","journal-title":"Nat Sci"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1001-1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000437382.03963.88"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/481095"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239048"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/632732"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12081115"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1410701"},{"issue":"01","key":"e_1_2_11_21_1","first-page":"345","article-title":"Update in preeclampsia","volume":"5","author":"Calvo P","year":"2020","journal-title":"Rev M\u00e9d Sinerg"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9060143"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.10.003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0285-5"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/172808"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/cen-09148-cover"},{"key":"e_1_2_11_27_1","article-title":"Early pregnancy prediction of preeclampsia","author":"Norwitz E","year":"2018","journal-title":"UpToDate"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2013.011"},{"issue":"2","key":"e_1_2_11_29_1","first-page":"425","article-title":"Mean platelet volume increases in type 2 diabetes mellitus independent of HbA1c level","volume":"30","author":"Cakir L","year":"2014","journal-title":"Acta Medica Mediterranea"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.15562\/bmj.v7i3.806"},{"key":"e_1_2_11_31_1","first-page":"292","article-title":"Are red cell distribution width and mean platelet volume associated with rheumatoid arthritis","volume":"27","author":"Cak\u0131r L","year":"2016","journal-title":"Biomed Res"},{"key":"e_1_2_11_32_1","first-page":"551","article-title":"Mean platelet volume: a simple indicator of chronic prostatitis. Acta Medica Mediterranea","volume":"29","author":"Aktas G","year":"2013","journal-title":"Acta Medica Mediterranea"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.21089\/njhs.33.0095"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002296"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.5114\/fmpcr.2020.95311"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3329\/jdnmch.v18i2.16018"},{"issue":"3","key":"e_1_2_11_37_1","first-page":"201","article-title":"Measurement of platelet parameters in normal and preeclamptic pregnant women","volume":"26","author":"Santos E","year":"2004","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"5","key":"e_1_2_11_38_1","first-page":"295","article-title":"Sample size calculation for epidemiologic studies: principles and methods","volume":"16","author":"Kamangar F","year":"2013","journal-title":"Arch Iran Med"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.9790\/0853-150750508"},{"key":"e_1_2_11_40_1","volume-title":"Anthropometry Procedures Manual for National Health and Nutrition Examination Survey","year":"2007"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4397"},{"issue":"1","key":"e_1_2_11_42_1","first-page":"425","article-title":"Evaluation of platelet indices and platelet counts and their significance in pre\u2010eclampsia and eclampsia","volume":"2","author":"Annam V","year":"2011","journal-title":"Int J Biol Med Res"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2012.704109"},{"issue":"1","key":"e_1_2_11_44_1","first-page":"28","article-title":"Platelet distribution width: a simple, practical and specific marker of activation of coagulation","volume":"14","author":"Vagdatli E","year":"2010","journal-title":"Hippokratia"},{"issue":"1","key":"e_1_2_11_45_1","first-page":"200","article-title":"The significance of platelet count, mean platelet volume and platelet width distribution in preeclampsia","volume":"11","author":"Alkholy EA\u2010M","year":"2013","journal-title":"Asian Acad Manag J"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2018.08.008"},{"issue":"2","key":"e_1_2_11_47_1","first-page":"57","article-title":"Validity of platelet indices in predicting the risk of developing preeclampsia","volume":"33","author":"Kurtoglu E","year":"2016","journal-title":"Clin Res"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10006-1164"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.06.006"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114488"},{"issue":"2","key":"e_1_2_11_51_1","first-page":"57","article-title":"The role of platelet parameters as a biomarker in the diagnosis and in predicting the severity of preeclampsia","volume":"2","author":"Amita K","year":"2015","journal-title":"Indian J Pathol Oncol"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojog.2015.512099"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12701"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2016.020"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.9734\/IBRR\/2014\/3018"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2017.03.012"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845413Y.0000000098"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612458147"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.12.036"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:22:17Z","timestamp":1693005737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jcla.24305"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24305","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,24]]},"assertion":[{"value":"2021-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24305"}}