{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T04:09:04Z","timestamp":1773547744467,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011828","name":"Guangxi Zhuang Autonomous Region Health and Family Planning Commission","doi-asserted-by":"publisher","award":["Z20200744"],"award-info":[{"award-number":["Z20200744"]}],"id":[{"id":"10.13039\/501100011828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011828","name":"Guangxi Zhuang Autonomous Region Health and Family Planning Commission","doi-asserted-by":"publisher","award":["Z20210411"],"award-info":[{"award-number":["Z20210411"]}],"id":[{"id":"10.13039\/501100011828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study evaluated whether changes in homocysteine concentrations in pregnant women with preeclampsia (PE) might be useful for predicting foetal death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This study evaluated 1,368 PE women at two Chinese centres. Medical records were reviewed to collect data regarding maternal age, homocysteine concentrations and other clinical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal serum homocysteine concentrations were significantly higher in the group with PE than control. Significant differences (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) were also observed between the foetal death and survival groups in terms of body mass index, neonatal weight, previous deliveries, gestation length and adverse pregnancy history. Multivariate logistic regression analysis revealed that upper\u2010quartile homocysteine concentration was a significant risk factor of foetal death in the group with PE, and overall survival rate of patients with high homocysteine concentrations during pregnancy was significantly lower than those with low level (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that foetal death was associated with upper\u2010quartile homocysteine concentrations in the group with PE, it can be an indicator of foetal death throughout the pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24312","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T08:40:30Z","timestamp":1646383230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Estimation of homocysteine concentration as an indicator of foetal death in pregnant Chinese women with preeclampsia: A\u00a0case\u2013control study"],"prefix":"10.1002","volume":"36","author":[{"given":"Wanyuan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory The People\u2019s Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Maternal &amp; Child Health Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-3845","authenticated-orcid":false,"given":"Chunyun","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Maternal &amp; Child Health Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Maternal &amp; Child Health Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuoxin","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Maternal &amp; Child Health Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Maternal &amp; Child Health Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-0623","authenticated-orcid":false,"given":"Junpeng","family":"Jing","sequence":"additional","affiliation":[{"name":"Joint Inspection Center of Precision Medicine The People\u2019s Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2016-009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1572727"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2012.709290"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.097469"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4457-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1619-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834e4b0f"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.07.021"},{"key":"e_1_2_9_11_1","first-page":"2719","article-title":"Increased homocysteine levels exist in women with preeclampsia from early pregnancy","volume":"29","author":"Wadhwani NS","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2010.10.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041421"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601729"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2012.693985"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.905055"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2219-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/123024"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:23:19Z","timestamp":1693005799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jcla.24312"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24312","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]},"assertion":[{"value":"2021-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24312"}}