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Based on the existing <jats:italic>T. pallidum<\/jats:italic> of a cognitive framework, the first concerns involving <jats:italic>T. pallidum<\/jats:italic> or the bacteria protein directly acted on vascular endothelial cells of the host, the second concerns mainly involved in the process of <jats:italic>T. pallidum<\/jats:italic> infection in vivo blood lipid change, secretion of cytokines and the interactions between immune cells indirectly. Through both direct and indirect influence, this study explores the role of host by <jats:italic>T. pallidum<\/jats:italic> infect in the process of the vascular endothelium.<\/jats:p>","DOI":"10.1002\/jcla.24318","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T05:05:02Z","timestamp":1646975102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Possible effects of <i>Treponema pallidum<\/i> infection on human vascular endothelial cells"],"prefix":"10.1002","volume":"36","author":[{"given":"Bibo","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province Hengyang Medical College University of South China  Hengyang P.R. 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