{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:55:11Z","timestamp":1790916911570,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005716","name":"Babol University of Medical Sciences","doi-asserted-by":"publisher","award":["4897"],"award-info":[{"award-number":["4897"]}],"id":[{"id":"10.13039\/501100005716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Loci controlling DNA double\u2010strand breaks (DSBs) repair play an important role in defending against the harmful health effects of benzene, toluene, ethylbenzene, and xylene (BTEX), but their gene variants may alter their repair capacity. The aim of the current study was to determine the relationship of functional polymorphisms ATM\u2010rs228589 A&gt;T, WRN\u2010rs1800392 G&gt;T and H2AX\u2010rs7759 A&gt;G in DBS repair loci with the abnormal hematological indices in workers who exposed to BTEXs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 141 cases with one or more abnormal hematological parameters, who had been occupationally exposed to BTEX chemicals and 152 controls with a similar exposure condition but without any abnormal hematological parameters. Atmospheric concentrations of BTEXs were measured and whole blood samples were taken from the participants to determine hematologic parameters and SNP genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that T allele of ATM\u2010rs228589 and G allele of H2AX\u2010rs7759 had a higher frequency in cases than controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, respectively). Also, AT and TT genotypes of ATM\u2010rs228589 and AG and GG genotypes of H2AX\u2010rs7759 were higher in cases compared to controls. The AT and TT genotypes of ATM\u2010rs228589 have significant associations with a risk of hematological abnormalities in the codominant (AT vs. AA, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018), dominant (AT\u00a0+\u00a0TT vs. AA, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.010) and overdominant (AT vs. AA\u00a0+\u00a0TT, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037) models. The GG and AG genotypes of H2AX\u2010rs7759 were in relation with increased risk of abnormal hematological indices under codominant (GA vs. AA, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009 &amp; GG vs. AA, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005), dominant (AG\u00a0+\u00a0GG vs. AA, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), and recessive (GG vs. AA\u00a0+\u00a0AG, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.025) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These observations may help to understand the mechanisms of BTEX hematotoxicity and identify useful biomarkers of risk assessment for workers exposed to BTEX.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24321","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T20:13:57Z","timestamp":1646252037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic variations in <i>ATM<\/i> and <i>H2AX<\/i> loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2684-7528","authenticated-orcid":false,"given":"Samaneh","family":"Jafari Roshan","sequence":"first","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences  Babol Iran"},{"name":"Department of Medical Genetics School of Medicine Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Mansoori","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Reza","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center Health Research Institute Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Sabour","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics School of Medicine Babol University of Medical Sciences  Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-835X","authenticated-orcid":false,"given":"Abdolreza","family":"Daraei","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center Health Research Institute Babol University of Medical Sciences  Babol 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