{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:52:30Z","timestamp":1790268750250,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700117"],"award-info":[{"award-number":["81700117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770110"],"award-info":[{"award-number":["81770110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770118"],"award-info":[{"award-number":["81770118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870101"],"award-info":[{"award-number":["81870101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970115"],"award-info":[{"award-number":["81970115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970116"],"award-info":[{"award-number":["81970116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aimed to investigate the balance between the mRNA levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in CD8+ T cells of patients with severe aplastic anemia (SAA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty untreated SAA patients, 18 remission SAA patients (R\u2010SAA), and 22 normal controls were evaluated. The mRNA expression levels of HATs, HDACs, and <jats:italic>IFNG<\/jats:italic> in CD8+ T cells were measured by real\u2010time quantitative reverse transcription polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histone acetylase <jats:italic>EP300<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic> mRNA levels were significantly elevated in CD8+ T cells of SAA patients compared with the normal controls (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). No significant differences were observed in <jats:italic>HDAC1<\/jats:italic> and <jats:italic>HDAC7<\/jats:italic>\u00a0mRNA between SAA patients and the normal controls. There was an obvious positive correlation between <jats:italic>IFNG<\/jats:italic> and <jats:italic>EP300<\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.5126, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), and <jats:italic>CREBBP<\/jats:italic> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.4663, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), respectively, in SAA and R\u2010SAA patients. In addition, <jats:italic>EP300<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic> mRNA levels were clearly correlated with clinical parameters of peripheral blood and bone marrow in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that <jats:italic>EP300<\/jats:italic> and <jats:italic>CREBBP<\/jats:italic> are increased in CD8+ T cells of SAA patients and are correlated with disease severity. The imbalances in HATs and HDACs may play a role in activating CD8+ T cells to promote the immune pathogenesis of SAA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24339","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T05:10:07Z","timestamp":1646975407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Abnormal expression of histone acetylases in CD8+ T cells of patients with severe aplastic anemia"],"prefix":"10.1002","volume":"36","author":[{"given":"Weiwei","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital  Tianjin 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