{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:25Z","timestamp":1753869385428,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Teratoma with nephroblastoma (TWN) is an extremely rare condition. Since 1984, only 45 reported cases have been identified. To our knowledge, there have been only two cases of TWN of ovarian origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We described a case of ovarian TWN who presented to us with painless abdominal masses 6\u00a0months after undergoing right ovarian cystectomy. The tumor had spread to the abdomen due to spontaneous rupture of the ovarian cyst and failure to undergo chemotherapy. Microscopically, the ovarian mass exhibited the typical components of a mature cystic teratoma. The tumors found in both the ovary and abdomen contained the nephroblastoma components and were strongly positive for WT\u20101. The patient was advised to undergo chemotherapy and she was lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A careful histological examination is necessary for an accurate diagnosis, which is based on morphology and extensive immunohistochemical studies. According to the literature, surgical excision alone seems reasonable as the prognosis of TWN is considered to be good. However, due to the spontaneous rupture of the ovarian cyst, chemotherapy of the patient after the first surgery was necessary in our case. Therefore, additional case studies are needed to clarify the standardized treatment of TWN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24364","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T17:25:16Z","timestamp":1648574716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A case of ovarian Teratoma with nephroblastoma presenting abdomen metastasis"],"prefix":"10.1002","volume":"36","author":[{"given":"Yinan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu","family":"Chu","sequence":"additional","affiliation":[{"name":"Obstetrical Department Lianyungang Maternal and Child Health Hospital  Lianyungang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beharee","family":"Nitish","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-1462","authenticated-orcid":false,"given":"Xinyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Jiangsu Cancer Hospital &amp; Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.112248"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840501)53:9<1936::AID-CNCR2820530922>3.0.CO;2-W"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(88)80328-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2016.12.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13887"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.05.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2018.07.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1990.5.4.237"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"061","article-title":"Teratoid Wilms tumor: report of three cases and review of the literature","volume":"35","author":"Al Ghamdi D","year":"2019","journal-title":"Turk J Pathol"},{"key":"e_1_2_7_12_1","first-page":"15","article-title":"Nephroblastic elements in a retroperitoneal immature teratoma with elevated serum alpha\u2010fetoprotein","volume":"2","author":"Cheng CH","year":"2016","journal-title":"J Case Rep Images Pathol"},{"issue":"11","key":"e_1_2_7_13_1","first-page":"8211","article-title":"Sacrococcygeal teratoma with nephroblastic elements: a case report and review of literature","volume":"7","author":"Ma Y","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_14_1","unstructured":"StantonAEIII.Pediatric Teratomas and Other Germ Cell Tumors. 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