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It seems that there is an association between blood cancer and an increased risk of severe COVID\u201019. This study aimed to review the literature reporting the COVID\u201019 outcomes in patients with hematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>In this systematic review and meta\u2010analysis, Pubmed, Embase, and Web of Science databases were searched using the following keywords: COVID\u201019, SARS\u2010CoV\u20102, blood cancer, myeloma, lymphoma, and leukemia. All the published articles in English from January 1, 2019, until March 10, 2021 were collected and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 53 studies with 2395 patients were included based on inclusion criteria. Most of these studies took place in Spain (14.81%), followed by the USA (11.11%), China (9.26%), and the UK (9.26%). More than half of COVID\u201019 patients with hematological malignancy were male (56.73%). Oxygen therapy played an important role in COVID\u201019 treatment. Moreover, anticoagulant therapies such as enoxaparin and heparin were two great assists for these patients. Fever (74.24%), cough (67.64%), and fatigue (53.19%) were the most reported clinical manifestations. In addition, hypertension and dyslipidemia were the most common comorbidities. The mortality rate due to COVID\u201019 in patients with hematological malignancies was 21.34%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that hematologic cancer patients were more susceptible to a severe COVID\u201019 than patients without blood cancer. Thus, the management of COVID\u201019 in these patients requires much more attention, and their screening should perform regularly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24387","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T11:34:06Z","timestamp":1649244846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comorbidities and mortality rate in COVID\u201019 patients with hematological malignancies: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Adel","family":"Naimi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Yashmi","sequence":"additional","affiliation":[{"name":"Student Research Committee Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-8123","authenticated-orcid":false,"given":"Reza","family":"Jebeleh","sequence":"additional","affiliation":[{"name":"Student Research Committee Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Imani Mofrad","sequence":"additional","affiliation":[{"name":"Student Research Committee Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakiba","family":"Azimian Abhar","sequence":"additional","affiliation":[{"name":"Student Research Committee Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Jannesar","sequence":"additional","affiliation":[{"name":"Student Research Committee Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-5017","authenticated-orcid":false,"given":"Mohsen","family":"Heidary","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center Sabzevar University of Medical Sciences  Sabzevar Iran"},{"name":"Department of Laboratory Sciences School of Paramedical Sciences Sabzevar University of Medical Sciences  Sabzevar Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Pakzad","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Faculty of Health Ilam University of Medical Sciences  Ilam Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000947"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.08.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30150-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0422"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.662746"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.738915"},{"key":"e_1_2_9_9_1","article-title":"Challenges posed by COVID\u201019 in cancer patients: a narrative review","author":"Mohseni Afshar Z","year":"2021","journal-title":"Cancer Med"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_9_11_1","unstructured":"Institute J.The Joanna Briggs Institute Critical Appraisal Tools for Use in JBI Systematic Reviews Checklist for Analytical Cross Sectional Studies. 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