{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:10Z","timestamp":1789500610969,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Sepsis is a highly life\u2010threatening disease. Long non\u2010coding RNA urothelial carcinoma associated 1 (lncRNA UCA1) participates in the processes of inflammation and organ injury in several diseases, whereas its role in sepsis patients is still unclear. The aim was to explore the clinical value of lncRNA UCA1 in sepsis patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred seventy\u2010four sepsis patients and 100 age and gender\u2010matched controls were enrolled. LncRNA UCA1 in peripheral blood mononuclear cell samples was examined, and the level of inflammatory cytokines in serum samples was assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>LncRNA UCA1 was highly expressed in sepsis patients compared with controls. LncRNA UCA1 was positively correlated with tumor necrosis factor\u2010\u03b1, interleukin (IL)\u20106, IL\u201017, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in sepsis patients, while it was not correlated with these inflammatory cytokines in controls. lncRNA UCA1 upregulation was related to raised APACHE II score and SOFA score in sepsis patients. Moreover, lncRNA UCA1 was increased in sepsis deaths compared with sepsis survivors and was independently correlated with increased 28\u2010day sepsis mortality risk. Further receiver operating characteristic curves presented that lncRNA UCA1\u00a0had a good value to predict 28\u2010motality risk, while its combination with other independent factors (including age, history of chronic kidney disease, G+ bacterial infection, Fungus infection, C\u2010reactive protein, and APACHE II score) exerted a great predictive value for 28\u2010day mortality risk.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>LncRNA UCA1 is upregulated and correlates with multiple pro\u2010inflammatory cytokines, terrible disease severity, and poor prognosis in sepsis patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24392","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T09:05:19Z","timestamp":1650445519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Involvement of blood lncRNA UCA1 in sepsis development and prognosis, and its correlation with multiple inflammatory cytokines"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-372X","authenticated-orcid":false,"given":"Jingmei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine HanDan Central Hospital Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology HanDan Central Hospital Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-2681","authenticated-orcid":false,"given":"Yiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology HanDan Central Hospital Handan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine HanDan Central Hospital Handan 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