{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:07:54Z","timestamp":1778623674388,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To explore the serum tumor necrosis factor\u2010alpha stimulated gene\u20106 (TSG\u20106) level and its association with disease activity in rheumatoid arthritis (RA) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 176 RA patients, 178 non\u2010RA patients (lupus erythematosus, osteoarthritis, ulcerative colitis, ankylosing spondylitis and psoriasis) and 71\u00a0healthy subjects. Serum TSG\u20106\u00a0levels were detected by enzyme\u2010linked immunosorbent assay (ELISA). RA patients were divided into inactive RA and active RA groups by disease activity score of 28 joints based on C\u2010reactive protein (DAS28\u2010CRP). The receiver operating characteristic (ROC) curve and Spearman's rank correlation test analyzed the correlation between TSG\u20106 concentration and RA disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumor necrosis factor\u2010alpha stimulated gene\u20106\u00a0levels in the RA group were increased (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). TSG\u20106 concentrations indicated an upward tendency with increased disease activity; The area under the curve (AUC) of TSG\u20106 for diagnosing RA and assessing the severity of RA were 0.78 and 0.80, respectively; The combination of TSG\u20106 and anti\u2010mutated citrullinated vimentin antibodies (anti\u2010MCV) (sensitivity:98.4%)improved the diagnostic accuracy of RA. Binary logistic regression analysis showed that TSG\u20106 was an independent risk factor related to the severity of RA, and OR (95% CI) was 1.2 (1.003\u20131.453).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TSG\u20106\u00a0levels in RA patients were elevated and related to disease activity. Therefore, TSG\u20106\u00a0may serve as a new potential biomarker for evaluating RA disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24395","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T20:48:54Z","timestamp":1648673334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tumor necrosis factor\u2010alpha stimulated gene\u20106: A biomarker reflecting disease activity in rheumatoid arthritis"],"prefix":"10.1002","volume":"36","author":[{"given":"Tingting","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Laboratory Medicine  Nanchang China"},{"name":"School of Public Health of Nanchang University  Nanchang 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