{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:54:22Z","timestamp":1778633662278,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The increase in rare opportunistic microbial infections caused by <jats:italic>Morganella morganii<\/jats:italic> is alarming across the globe. It has been reported that in cases of urinary tract infections (UTIs) caused by <jats:italic>M.\u00a0morganii<\/jats:italic>, however, few studies investigated children. Our study aimed to analyze the risk factors, antimicrobial susceptibility, and clinical characteristics, so as to improve the clinical diagnosis and therapy of <jats:italic>M.\u00a0morganii<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between April 1, 2017 and April 1, 2021, 11 cases of pediatric UTIs caused by <jats:italic>M.\u00a0morganii<\/jats:italic> were included in this retrospective study. Medical records were reviewed and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 10 males and one female between 11\u00a0months and 13\u00a0years old (mean age: 4\u00a0years 9\u00a0months). The most common comorbidity was nephrotic syndrome (72.7%, 8\/11). Six patients (54.5%) were in the immunosuppressed state due to chemotherapy or immunosuppressant therapy. Ten cases defined as lower UTIs with no specific clinical manifestations had normal or slightly elevated leukocyte counts and procalcitonin (PCT) levels, and normal C\u2010reactive protein (CRP) levels. One child diagnosed upper UTIs accompanied with fever, high level of leukocyte counts, CRP, and PCT. The <jats:italic>M.\u00a0morganii<\/jats:italic> presented 100% susceptibility to aztreonam, ertapenem, meropenem, piperacillin\/tazobactam, cefepime, ceftazidime, cefotetan, ticarcillin\/clavulanic acid, and cefoperazone\/sulbactam. Almost all patients had good responses to third\u2010generation cephalosporins antibiotic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical vigilance for the possibility of <jats:italic>M.\u00a0morganii<\/jats:italic> in pediatric UTIs in combination with underlying disease or immunosuppression is warranted. Treatment strategies should be proposed according to the clinical condition and the antibiotic susceptibility results.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24399","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T17:15:14Z","timestamp":1648574114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["<i>Morganella morganii<\/i>: An unusual analysis of 11 cases of pediatric urinary tract infections"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-0677","authenticated-orcid":false,"given":"Huixuan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Xiamen University  Xiamen China"},{"name":"Pediatric Key Laboratory of Xiamen  Xiamen China"},{"name":"Institute of Pediatrics School of Medicine Xiamen University  Xiamen 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