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By definition, reinfection denotes severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), PCR redetection, and COVID\u201019 recurrence within three months of the initial symptoms. The main aim of the current systematic review was to evaluate the features of COVID\u201019 relapse patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>For this study, we used a string of terms developed by a skilled librarian and through a systematical search in PubMed, Web of Science, and Embase for eligible studies. Clinical surveys of any type were included from January 2019 to March 2021. Eligible studies consisted of two positive assessments separated by a negative result via RT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four studies included 207 cases of COVID\u201019 reinfection. Children were less likely to have COVID\u201019 relapse. However, the most patients were in the age group of 20\u201340\u00a0years. Asthenia (66.6%), headache (66.6%), and cough (54.7%) were prevalent symptoms in the first SARS\u2010CoV\u20102 infection. Asthenia (62.9%), myalgia (62.9%), and headache (61.1%) were most frequent in the second one. The most common treatment options used in first COVID\u201019 infection were lopinavir\/ritonavir (80%), oxygen support (69.2%), and oseltamivir (66.6). However, for the treatment of second infection, mostly antibiotics (100%), dexamethasone (100%), and remdesivir (80%) were used. In addition, obesity (32.5%), kidney failure (30.7%), and hypertension (30.1%) were the most common comorbidities. Unfortunately, approximately 4.5% of patients died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found the potency of COVID\u201019 recurrence as an outstanding issue. This feature should be regarded in the COVID\u201019\u00a0management. Furthermore, the first and second COVID\u201019 are similar in clinical features. For clinically practical comparison of the symptoms severity between two epochs of infection, uniform data of both are required. 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