{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T11:23:46Z","timestamp":1768994626008,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue lymphoma translocation protein 1 (MALT1) correlates with treatment outcomes in inflammatory bowel disease and rheumatoid arthritis (RA). This study aimed to further evaluate the MALT1\u00a0longitudinal change and its relationship with tumor necrosis factor inhibitors (TNFi) response in RA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one RA patients receiving TNFi [etanercept (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) or adalimumab (<jats:italic>n<\/jats:italic>\u00a0=\u00a029)] were enrolled. MALT1 was detected by RT\u2010qPCR in peripheral blood samples of RA patients before treatment (W0), at week (W)4, W12, and W24 after treatment. RA patients were divided into response\/non\u2010response, remission\/non\u2010remission patients according to their treatment outcome at W24. Meanwhile, MALT1 was also detected by RT\u2010qPCR in 30 osteoarthritis patients and 30\u00a0healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue lymphoma translocation protein 1 was elevated in RA patients compared with HCs (<jats:italic>Z<\/jats:italic>=\u22126.392, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and osteoarthritis patients (<jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22125.020, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). In RA patients, MALT1 was positively correlated with C\u2010reactive protein (<jats:italic>r<jats:sub>s<\/jats:sub><\/jats:italic>\u00a0=\u00a00.347, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003), but not other clinical characteristics, treatment history, or current TNFi category. Meanwhile, MALT1 decreased from W0 to W12 in total RA patients (<jats:italic>x<jats:sup>2<\/jats:sup><\/jats:italic>\u00a0=\u00a086.455, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), etanercept subgroup (<jats:italic>x<jats:sup>2<\/jats:sup><\/jats:italic>\u00a0=\u00a046.636, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and adalimumab subgroup (<jats:italic>x<jats:sup>2<\/jats:sup><\/jats:italic>\u00a0=\u00a041.291, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Moreover, MALT1 at W24 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) was decreased in response patients compared with non\u2010response patients; MALT1 at W12 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.027) and W24 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.010) were reduced in remission patients than non\u2010remission patients. In etanercept subgroup, MALT1 at W24 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.013) was decreased in response patients compared with non\u2010response patients. In adalimumab subgroup, MALT1 at W24 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.015) was lower in remission patients than non\u2010remission patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mucosa\u2010associated lymphoid tissue lymphoma translocation protein 1 reduction after treatment is associated with response and remission to TNFi in RA patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24449","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T19:24:56Z","timestamp":1651519496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mucosa\u2010associated lymphoid tissue lymphoma translocation protein 1 in rheumatoid arthritis: Longitudinal change after treatment and correlation with treatment efficacy of tumor necrosis factor inhibitors"],"prefix":"10.1002","volume":"36","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaozhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-8285","authenticated-orcid":false,"given":"Anbing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Xiangyang Central Hospital Affiliated Hospital of Hubei University of Arts and Science  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112857"},{"issue":"3","key":"e_1_2_8_3_1","first-page":"389","article-title":"Epidemiology of rheumatoid arthritis, clinical aspects and socio\u2010economic determinants in Pakistani patients: a systematic review and meta\u2010analysis","volume":"69","author":"Naqvi AA","year":"2019","journal-title":"J Pak Med 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