{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:57:27Z","timestamp":1780581447249,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81320108016"],"award-info":[{"award-number":["81320108016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immunoglobulin\u2010A vasculitis (IgAV) is an immune\u2010related systemic vasculitis with an unclear etiology. Genetic predisposition is now considered to be closely associated with the development of the disease, and it is essential to reveal the relationship between them. To explore the role of heredity in the disease, we performed a genome\u2010wide association study (GWAS) of 496 IgAV cases and 7165 controls using an Illumina Infinium Global Screening Array chip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the first stage of analysis, a significant correlation between the major histocompatibility complex (MHC) and IgAV was observed. Subsequently, human leukocyte antigen (HLA) analysis was conducted using a new large\u2010scale Han\u2010MHC reference panel. Fine mapping of IgAV risk in the MHC region indicated that two amino acid positions, 120 and 11, of HLA\u2010DRB1 and three potential HLA alleles (HLA\u2010DRB1\u221704, HLA\u2010DRB1\u221716, and HLA\u2010DRB1\u221716:02) were significantly associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Further stepwise conditional analysis demonstrated that 3 amino acid positions (120, 26, 96) of HLA\u2010DRB1 and 6 HLA\u2010DRB1 alleles (HLA\u2010DRB1*04, HLA\u2010DRB1*16, HLA\u2010DRB1*01, HLA\u2010DRB1*12:02, HLA\u2010DRB1*10, and HLA\u2010DRB1*15:02) were independent signals. Among them, the most significant signal was HLA\u2010DRB1 amino acid Ser120 (OR\u00a0=\u00a01.59, <jats:italic>p<\/jats:italic>\u00a0=\u00a03.19\u00a0\u00d7\u00a010<jats:sup>\u22128<\/jats:sup>); no independent signal in the MHC region except for HLA\u2010DRB1 was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirms that the pathogenesis of IgAV has a genetic component and that HLA\u2010DRB1 is strongly associated with susceptibility to IgAV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24457","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T04:29:42Z","timestamp":1650947382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genome\u2010wide association study of 7661 Chinese Han individuals and fine\u2010mapping major histocompatibility complex identifies HLA\u2010DRB1 as associated with IgA vasculitis"],"prefix":"10.1002","volume":"36","author":[{"given":"Liang","family":"Xia","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of the First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"},{"name":"Department of Hematology The First Affiliated Hospital Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of the First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanshuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First 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Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of the First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of the First Affiliated Hospital Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology Anhui Medical University Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital Anhui Medical University  Hefei 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