{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:51:10Z","timestamp":1788580270584,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the expression of heat shock protein 90\u03b1 (HSP90\u03b1) in patients with lung cancer (LC) and the clinical value of HSP90\u03b1 and other related markers in the diagnosis of LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 335 patients enrolled in the study cohort, 175 were screened for LC and 160 were healthy (HC). The plasma levels of HSP90\u03b1 and related markers (CEA, NSE, CYFRA21\u20101 and ProGRP) were detected in all individuals in the cohort by enzyme\u2010linked immunosorbent assay (ELISA). Groups were divided according to gender (male\/female), age (\u226460\u00a0years\/&gt;60\u00a0years), types of LC (small\u2010cell carcinoma, squamous carcinoma and adenocarcinoma), staging (I, II, III and IV) and metastasis (metastasis and non\u2010metastasis) separately. Wilcoxon Mann\u2013Whitney test and Kruskal\u2013Wallis test were used to compare statistical differences between two groups\/among the multiple groups for each factor of HSP90\u03b1. The <jats:italic>r<\/jats:italic>\u2010value and Kappa were used to compare HSP90\u03b1 with related markers, and the receiver operating curve (ROC) was used to evaluate the efficacy of plasma HSP90\u03b1 in predicting LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistical difference was found in the plasma level of HSP90\u03b1 among different age and gender groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). In the group divided by LC type, staging and metastasis status, there were statistical differences among different groups in HSP90\u03b1 level (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The levels of HSP90\u03b1, CEA, NSE, CYFRA21\u20101 and ProGRP in LC groups were significantly higher than HC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). R values of HSP90\u03b1 correlated with other related markers in the diagnosis of LC (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Although HSP90\u03b1 and other related markers did not fit the satisfactory conformance, in terms of the positive rate of diagnosis, it was statistically differences in the diagnostic positive rate between HSP90\u03b1 and each marker (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). ROC analysis showed that a plasma HSP90\u03b1 cut\u2010off point of 50.02\u00a0ng\/ml had an optimal predictive value for LC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HSP90\u03b1 has significant clinical value in early screening and diagnosis of LC. The combined application of HSP90\u03b1 and related markers can improve the positive rate of early diagnosis of LC effectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24462","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T13:51:45Z","timestamp":1651845105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic value of HSP90\u03b1 and related markers in lung cancer"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3160-5956","authenticated-orcid":false,"given":"Zhimin","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Shaanxi Provincial Cancer Hospital Affiliated to Xi'an Jiao Tong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Xinhua Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlin","family":"Hong","sequence":"additional","affiliation":[{"name":"F&amp;E Data Technology (Tianjin) Corp  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shaanxi Provincial Cancer Hospital Affiliated to Xi'an Jiao Tong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shaanxi Provincial Cancer Hospital Affiliated to Xi'an Jiao Tong University  Xi'an 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