{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:46:37Z","timestamp":1789681597800,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatoma\u2010derived growth factor (HDGF) is reported to play an important role in tumorigenesis and cancer progression. However, growing evidence indicates its participation in immune system activation. This study analyzed the relationship among serum HDGF levels, disease activity, and laboratory markers in patients with rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples from 165 patients with RA, 42 with osteoarthritis (OA), and 28\u00a0healthy controls, were used to evaluate the serum HDGF levels. Correlations of serum HDGF levels with age, 28\u2010joint count disease activity score (DAS28), and laboratory findings were assessed by Pearson correlation and receiver operator characteristic (ROC) curve analyses to obtain HDGF optimal cutoffs according to the disease status. Immunohistochemical staining was performed on the knee synovial tissue samples from patients with RA and OA (<jats:italic>n<\/jats:italic>\u00a0=\u00a010 each) to investigate HDGF joint expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum HDGF levels were significantly correlated with DAS28 erythrocyte sedimentation rate (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.412, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and C\u2010reactive protein values (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.376, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). The optimal cutoffs of serum HDGF levels from the ROC analysis were 5.79 and 5.14 for the differentiation of active\/inactive disease and remission\/non\u2010remission, respectively. The ideal cutoff of serum HDGF levels to differentiate RA and OA was determined as 5.47. Serial serum HDGF level analyses in 21 patients with RA revealed that serum HDGF levels significantly decreased after improvement in disease activity (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.046). HDGF expression was not observed in the synovial tissues of the patients with RA and OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum HDGF level could be a potential laboratory biomarker for the severity of RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24474","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T19:55:01Z","timestamp":1651521301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of serum hepatoma\u2010derived growth factor levels with disease activity in rheumatoid arthritis: A pilot study"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-9880","authenticated-orcid":false,"given":"Sung Soo","family":"Ahn","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine Yongin Severance Hospital Yonsei University College of Medicine  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Yongin Severance Hospital Yonsei University College of Medicine  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-1495","authenticated-orcid":false,"given":"Younhee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Severance Hospital Yonsei University College of Medicine  Seoul South 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