{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:36:32Z","timestamp":1792449392790,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the value of the expression of serum miR\u201092 and miR\u2010122 combined with lung ultrasound score (LUS) in the prognosis of neonatal acute respiratory distress syndrome (ARDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      This study involved 148 neonatal ARDS cases from January 2018 to October 2021, of which 77 children were discharged from hospital and 31 died. The children with ARDS were classified according to disease severity based on X\u2010ray examination as mild (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a069 cases) and severe (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039 cases). The expression of serum miR\u201092 and miR\u2010122 was detected by real\u2010time fluorescence quantitative PCR and the LUS score was recorded. The data were subjected to ROC curve analysis and Pearson correlation analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression of serum miR\u201092, miR\u2010122, and LUS score in the patients that died were significantly higher than in those who survived (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). These indicators were also significantly higher in the severe disease group compared to the mild disease group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). ROC curve showed that serum miR\u201092 and miR\u2010122 combined with the LUS score had the largest area under the curve (0.920, 95% CI: 0.860\u20130.977) for predicting death, with a sensitivity and specificity of 92.0% and 87.0%, respectively. Pearson correlation analysis showed that the expression levels of serum miR\u201092 and miR\u2010122 were positively correlated with the LUS score (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increased expression of serum miR\u201092 and miR\u2010122 is related to the severity and prognosis of children with ARDS, combined with the LUS score are of value to predict the prognosis of children with ARDS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.24485","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:54:40Z","timestamp":1653519280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical value of serum miR\u201092 and miR\u2010122 expression level combined with pulmonary ultrasound score in the prognosis of neonatal acute respiratory distress syndrome"],"prefix":"10.1002","volume":"36","author":[{"given":"Haiyan","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Ultrasound Sanya Central Hospital  Sanya China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Haikou Maternal and Child Health Care Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-167X","authenticated-orcid":false,"given":"Renyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hainan Women and Children's Medical Center  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S340586"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.11.005"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"3381","article-title":"miR\u2010155, miR\u201096 and miR\u201099a as potential diagnostic and prognostic tools for the clinical management of hepatocellular carcinoma","volume":"18","author":"Ning S","year":"2019","journal-title":"Oncol Lett"},{"issue":"11","key":"e_1_2_10_5_1","first-page":"3167","article-title":"Evaluation of Mir\u2010224, Mir\u2010215 and Mir\u2010143 as serum biomarkers for HCV associated hepatocellular carcinoma","volume":"18","author":"Mamdouh S","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"3919","article-title":"Clinical value of miRNA\u2010122 in the diagnosis and prognosis of various types of cancer","volume":"17","author":"Dai M","year":"2019","journal-title":"Oncol Lett"},{"issue":"13","key":"e_1_2_10_7_1","first-page":"7196","article-title":"Effects of miR\u2010155 on proliferation and apoptosis by regulating FoxO3a\/BIM in liver cancer cell line HCCLM3","volume":"24","author":"Liao WW","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27956"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040864"},{"issue":"11","key":"e_1_2_10_10_1","first-page":"8046","article-title":"MicroRNA\u2010139\u20103p indicates a poor prognosis of colon cancer","volume":"7","author":"Liu X","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"1684","article-title":"MicroRNA449a is a potential predictor of colitisassociated colorectal cancer progression","volume":"40","author":"Feng Y","year":"2018","journal-title":"Oncol Rep"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020729"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0541-5"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"3174","article-title":"G994T polymorphism in exon 9 of plasma platelet\u2010activating factor acetylhydrolase gene and lung ultrasound score as prognostic markers in evaluating the outcome of acute respiratory distress syndrome","volume":"17","author":"Lv W","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30214-X"},{"issue":"8","key":"e_1_2_10_17_1","first-page":"9371","article-title":"Expression of miR\u2010192\u20105p in colon cancer serum and its relationship with clinicopathologic features","volume":"13","author":"Chen X","year":"2021","journal-title":"Am J Transl Res"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29678"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.18.03459-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-018-0370-1"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2105-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13144"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S335396"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S333904"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5220368"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204012"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.24485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.24485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:10:01Z","timestamp":1692742201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.24485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1002\/jcla.24485"],"URL":"https:\/\/doi.org\/10.1002\/jcla.24485","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"2022-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24485"}}