{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:33Z","timestamp":1753869393748,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013318","name":"ShanXi Science and Technology Department","doi-asserted-by":"publisher","award":["201901D211513"],"award-info":[{"award-number":["201901D211513"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Soluble suppression of tumorigenicity 2 (ST2) is closely related to the development of cardiovascular disease, but the level of acute coronary syndrome (ACS) and the relationship between ST2 and ACS are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Patients with the acute coronary syndrome were divided into the unstable angina pectoris (USAP) group (<jats:italic>n<\/jats:italic>\u00a0=\u200965) and non\u2010ST\u2010segment elevation myocardial infarction (NSTEMI) group (<jats:italic>n<\/jats:italic>\u00a0=\u200958), and the healthy population, without chest pain and with normal coronary CT, was included as a control group (<jats:italic>n<\/jats:italic>\u00a0=\u200955). Laboratory index levels were collected from each participant. The baseline information was reviewed and analyzed. The binary logistic regression was used to explore the relation of ST2 levels with the occurrence of ACS and NSTEMI, and the diagnostic performance of ST2 for diagnosing ACS or NSTEMI was evaluated using a receiver\u2010operating characteristic (ROC) curve.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of ST2 was found significantly higher in NSTEMI than in USAP and was higher in USAP than in control (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.01). ST2 levels were positively correlated with ALT, AST, and BNP in the control group, were negatively correlated with HGB and TG in the USAP group, and were positively correlated with WBC, GLU, BNP, and Gensini scores in the NSTEMI group. Multivariate analysis revealed that the occurrence of ACS was associated with ST2, BNP, GLU, TC, BUN, WBC, and PLT, and the occurrence of NSTEMI was associated with AST, WBC, LDL\u2010C, and ST2. Meanwhile, ST2 levels achieved good performance for ACS and NSTEMI diagnostician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ST2 could be used as an auxiliary diagnostic indicator for the occurrence of ACS and NSTEMI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.24511","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T01:49:20Z","timestamp":1653529760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic efficacy of serum ST2 in patients with ASC"],"prefix":"10.1002","volume":"36","author":[{"given":"Yaping","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"},{"name":"Emergency Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[{"name":"Emergency Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"},{"name":"Emergency Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-5781","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"},{"name":"Emergency Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336154"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015539"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-016-0939-y"},{"key":"e_1_2_8_5_1","first-page":"11","article-title":"Acute coronary syndrome: presentation and diagnostic evaluation","volume":"490","author":"Barstow C","year":"2020","journal-title":"FP Essent"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.02.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00357"},{"issue":"10","key":"e_1_2_8_8_1","first-page":"831","article-title":"2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST\u2010segment elevation. 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